This Hormone-related Focused Library has been designed to support hormone-related research, high-throughput screening, and drug discovery projects. It comprises over 1,500 screening molecules synthesized in-house, including analogs of human and animal hormones/hormone-related agents (approximately 1,400 compounds), as well as plant hormones (around 40 compounds). Additionally, a subset of 90 steroid-like compounds based on a gonane scaffold was integrated into this Screening Set. These screening compounds were meticulously selected from our proprietary HTS Compound Collection through a 2D fingerprint similarity search with a Tanimoto cut-off greater than 0.75.
The compound selection can be customized based on your requirements, cherry picking is available.
Please, contact us at orders@lifechemicals.com for any additional information and price quotations.
Background
Human and animal hormones serve as messengers to carry out precise regulatory functions within the cells of their respective effector organs. They play a pivotal role in controlling various physiological processes. Hormones and their derivatives are instrumental in hormonal therapy, a treatment modality that involves adding, blocking, or removing hormones. This therapeutic approach is particularly advantageous in slowing down or halting the growth of cancer cells, which depend on hormones for proliferation. Hormones exhibit diverse chemical structures, primarily falling into three classes: eicosanoids, steroids, and amino acid/protein derivatives.
On the other hand, plant hormones are crucial biochemical compounds that profoundly influence plant growth and crop yield, especially under varying environmental conditions, including stress. Early research into plant hormones identified five major classes: abscisic acid, auxin, cytokinins, ethylene, and gibberellins. These hormones have extensive applications in agriculture as targeted treatment agents, serving purposes such as weed control or rooting enhancement. Additionally, they can facilitate flowering and augment fruit size.
Figure 1. Examples of various hormones and neurotransmitters [1].
Analogs of human and animal hormones and hormone-related agents
Analogs of plant hormones
Steroid-like compounds based on a gonane scaffold
References:
- Hadacek F, Bachmann G. Low-molecular-weight metabolite systems chemistry. Frontiers in Environmental Science. 2015; 4. doi: 10.3389/fenvs.2015.00012 https://www.frontiersin.org/files/Articles/128574/fenvs-03-00012-HTML/image_m/fenvs-03-00012-g002.jpg