Please sign in to download the files. A new tab will open where you can login/register.

Login

Pre-plated Focused Libraries

Download SD Files (.sdf):

Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

Please, contact us at orders@lifechemicals.com for any additional information and price quotations.

Key features

  • Novel screening compounds synthesized in-house
  • Several formatting options available in 384- or 96-well microplates
  • Competitive pricing and convenient terms
  • Application of rigorous drug-likeness filters
  • Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
  • Guaranteed hit re-supply, product scale-up
  • Compound library design and combinatorial synthesis based on found hits

Formatting

  • 384-well PP-masterblocks, Greiner bio-one ref: 781280 or 784201, V-bottom microtiter plate
  • 96-well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0 ml microplate capped with capmats, Greiner bio-one ref.# 381070
  • 96-well plates, Matrix cat.# 4247, racked round-bottom tubes, 1.4 ml capped tubes with cap-strips cat.#4413 or cap-mats cat.# 4430

Pre-plated 3D-shaped Screening Sets

Four non-overlapping sets of structurally-diverse screening compounds, totaling 8,640, 6,400, 4,245, and 3,520 3D-like molecules have been prepared as an efficient starting point for both phenotypic and target-based HTS in drug discovery projects. These sets are complementary, offering flexibility in combination to form larger supersets of 12,160 or 18,560 and even up to 22,805 non-planar sp3-rich molecules.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

3D-Set_1-384w 

8640

10 mM DMSO solution

5/10/20/25/50 uL

27

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

3D-Set_1-96w

8640

10 mM DMSO solution

5/10/20/25/50 uL

108

96-well microplate, 80 compounds per plate; 1, 12 columns empty

3D-Set_2-384w

6400

10 mM DMSO solution

5/10/20/25/50 uL

20

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

3D-Set_2-96w

6400

10 mM DMSO solution

5/10/20/25/50 uL

80

96-well microplate, 80 compounds per plate; 1, 12 columns empty

3D-Set_3-384w

4245

10 mM DMSO solution

5/10/20/25/50 uL

14

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

3D-Set_3-96w

4245

10 mM DMSO solution

5/10/20/25/50 uL

53

96-well microplate, 80 compounds per plate; 1, 12 columns empty

3D-Set_4-384w

3520

10 mM DMSO solution

5/10/20/25/50 uL

11

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

3D-Set_4-96w

3520

10 mM DMSO solution

5/10/20/25/50 uL

44

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a comprehensive description and additional formatting choices, please consult our full collection of 3D Compound Libraries for HTS. You can also be interested in our related products:

 

Pre-plated Antibacterial Screening Library

10,880 drug-like screening compounds with potential antibacterial activity against different gram-positive and gram-negative bacteria species and bacteria-related protein targets, selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Antibacterial-1

10880

10 mM

DMSO solution

5/10/20/25/50 uL

34

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Antibacterial-2

10880

10 mM

DMSO solution

50 uL

136

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Antibacterial Screening Compound Library.

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

ATPase-1

7300

10 mM

DMSO solution

5/10/20/25/50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

ATPase-2

7300

10 mM

DMSO solution

50 uL

92

96-well microplate, 80 compounds per plate;
1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full ATPase Focused Libraries.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Bioactive-1

8000

10 mM

DMSO solution

5/10/20/25/50 uL

25

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

 For a detailed description and other formatting options, please, refer to the full Biologically Active Compound Library.

Pre-plated CNS Screening Library

7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

CNS-Set-1

7100

10 mM

DMSO solution

5/10/20/25/50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

CNS-Set-2

7100

10 mM

DMSO solution

100 uL

89

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full CNS Screening Library.

Pre-plated Coronavirus COVID-19 Screening Set

2,300 drug-like screening compounds from 2019-nCoV Main Protease Targeted Library to facilitate anti-coronavirus drug discovery projects.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

COVID-Set-1

2300

10 mM DMSO solution

5/10/20/25/50 uL

8

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

For a detailed description of different coronavirus-related screening libraries and other formatting options, please, refer to the full collection of Coronavirus Screening Libraries.

Pre-plated Cysteine Focused Covalent Inhibitor Library

3,520 potential cysteine covalent binders from the Cys-focused Diversity Screening Set. The screening compounds were selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-CovInh-1

3520

10 mM

DMSO solution

5/10/20/25/50 uL

11

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-CovInh-2

3520

10 mM

DMSO solution

100 uL

44

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Cysteine Focused Covalent Inhibitor Library.

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-Protease-1

3200

10 mM

DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-Protease-2

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate;

1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Cysteine Protease Focused Library.

Pre-plated Deubiquitinase Screening Set

3,200 drug-like screening compounds of potential deubiquitinase modifiers selected with receptor-based drug design methods.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

DUB-1

3200

10 mM

DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

DUB-2

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate;

1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Deubiquitinase Targeted Library within the Deubiquitinase Screening Libraries.

Pre-plated Fsp3 Screening Set

10,560 Fsp3-enriched screening compounds with average Fsp3 count 0.56 (cut-off ≥0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house MedChem filters.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Fsp3-Set-1

10560

10 mM

DMSO solution

5/10/20/25/50 uL

33

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Fsp3-Set-2

10560

10 mM

DMSO solution

100 uL

132

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Fsp³-enriched Screening Compound Library.

Pre-plated Helicase Screening Sets

6,080 drug-like small-molecule compounds with potential helicase-related activity for drug discovery in areas of infectious diseases and cancer. Alternatively, two smaller complementary and non-overlapping subsets of 3,520 and 2,560 helicase-focused molecules are also purchasable separately in the pre-plated format.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Helicase-Set-384w

6080

10 mM DMSO solution

5/10/20/25/50 uL

19

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Helicase-Set-96w

6080

10 mM DMSO solution

5/10/20/25/50 uL

76

96-well microplate, 80 compounds per plate; 1, 12 columns empty

Helicase-Subset_1-384w

3520

10 mM DMSO solution

5/10/20/25/50 uL

11

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Helicase-Subset_1-96w

3520

10 mM DMSO solution

5/10/20/25/50 uL

44

96-well microplate, 80 compounds per plate; 1, 12 columns empty

Helicase-Subset_2-384w

2560

10 mM DMSO solution

5/10/20/25/50 uL

8

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Helicase-Subset_2-96w

2560

10 mM DMSO solution

5/10/20/25/50 uL

32

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to our full Helicase Screening Libraries.

 

Pre-plated Ion Channel Diversity Set

2,240 duplicates and close analogs of reported ion channel inhibitors. The compounds were selected based on several chemoinformatics methods.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Ion_Channel-1

2240

10 mM DMSO solution

5/10/20/25/50 uL

7

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Ion_Channel-2

2240

10 mM DMSO solution

100 uL

28

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For more details, broader compound selection and other formatting options, please, refer to our main collection of Ion Channel Screening Libraries.

Pre-plated Kinase Diversity Screening Set

2,000 potential small-molecule kinase inhibitors with optimal physicochemical properties and maximal diversity for immunology and cancer-related drug discovery.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Kinase-Lib-1

2000

10 mM

DMSO solution

5/10/20/25/50 uL

7

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Kinase-Lib-2

2000

10 mM

DMSO solution

100 uL

25

96-well microplate, 80 compounds per plate; 1, 12 columns empty

 For a detailed description and other formatting options, please, refer to the Protein Kinase Diversity Set.

Pre-plated PI3K/Akt/mTOR Screening Set

4,427 small-molecule screening compounds with potential inhibitory activity against the PI3K/Akt/mTOR pathway, aimed for anticancer drug discovery.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

PI3K-Lib-1

4427

10 mM

DMSO solution

5/10/20/25/50 uL

14

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

PI3K-Lib-2

4427

10 mM

DMSO solution

100 uL

56

96-well microplate, 80 compounds per plate; 1, 12 columns empty

 For a detailed description and other formatting options, please, refer to the PI3K/Akt/mTOR Focused Library.

Pre-plated PPI-focused Screening Set

6,080 small-molecule potential PPI binders, selected based on proprietary PPI Focused Library by Machine Learning (Decision Tree) Method.

Download the full list of compounds (SD File) here. 

Catalog ID

Compounds

Concentration

Volume

Plates

Format

PPI-Lib-1

6080

10 mM DMSO solution

5/10/20/25/50 uL

19

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

For a detailed description and other formatting options, please, refer to our collection of related Protein-Protein Interaction Screening Libraries:

Pre-plated RNA Diversity Screening Sets

Three non-overlapping sets of 1,600, 3,200, and 5,120 drug-like small-molecule compounds with predicted RNA-targeting activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research. Combining these subsets allows the formation of a more extensive assay-ready screening library of 9,920 molecules.

Download the full list of compounds (SD File) here. 

Catalog ID

Compounds

Concentration

Volume

Plates

Format

RNA-Set-1-384w

1600

10 mM DMSO solution

5/10/20/25/50 uL

5

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Set-2-384w

3200

10 mM DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Set-3-384w

5120

10 mM DMSO solution

5/10/20/25/50 uL

16

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Div-Superset-384w

9920

10 mM DMSO solution

5/10/20/25/50 uL

31

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

For a detailed description and other formatting options, please, refer to the full RNA Screening Libraries.

Pre-plated RNA Focused Sets

Three Screening Sets of small-molecule compounds with with potential inhibitory activity against RNA based on different RNA Screening Libraries:

  • 5,120 small molecules with the potential to target human RNA
  • 960 drug-like screening compounds selected through Bayesian modeling
  • 3,300 compounds from various screening sets bearing structural similarity to reported RNA inhibitors

Catalog ID

Compounds

Concentration

Volume

Plates

Format

RNA-Human-Set-384w

5120

10 mM DMSO solution

5/10/20/25/50 uL

16

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Bayes-Set-384w

960

10 mM DMSO solution

5/10/20/25/50 uL

3

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Similarity-Set-384w

3300

10 mM DMSO solution

5/10/20/25/50 uL

11

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

RNA-Similarity-Set-96w

3300

10 mM DMSO solution

50/100 uL

42

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full RNA Screening Libraries.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. By using our website, you accept our conditions of use of cookies to track data and create content (including advertising) based on your interest. Accept