Pre-plated Focused Libraries

Download SD Files (.sdf):

Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

Key features

  • Novel screening compounds synthesized in-house
  • Several formatting options available in 384- or 96-well microplates
  • Competitive pricing and convenient terms
  • Application of rigorous drug-likeness filters
  • Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
  • Guaranteed hit re-supply, product scale-up

Formatting

  • 384-well PP-masterblocks, Greiner bio-one ref: 781280 or 784201, V-bottom microtiter plate
  • 96-well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0 ml microplate capped with capmats, Greiner bio-one ref.# 381070
  • 96-well plates, Matrix cat.# 4247, racked round-bottom tubes, 1.4 ml capped tubes with cap-strips cat.#4413 or cap-mats cat.# 4430

Please, contact us at orders@lifechemicals.com for details and price quotations.

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

ATPase-1

7300

10 mM

DMSO solution

5/10/20/25/50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

ATPase-2

7300

10 mM

DMSO solution

50 uL

92

96-well microplate, 80 compounds per plate;
1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full ATPase Focused Libraries.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Bioactive-1

8000

10 mM

DMSO solution

5/10/20/25/50 uL

25

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

 For a detailed description and other formatting options, please, refer to the full Biologically Active Compound Library.

Pre-plated CNS Screening Library

7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

CNS-Set-1

7100

10 mM

DMSO solution

5/10/20/25/50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

CNS-Set-2

7100

10 mM

DMSO solution

100 uL

89

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full CNS Screening Library.

Pre-plated Coronavirus COVID-19 Screening Set

2,300 drug-like screening compounds to facilitate anti-coronavirus drug discovery projects.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

COVID-Set-1

2300

10 mM DMSO solution

5/10/20/25/50 uL

8

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

For a detailed description of different coronavirus-related screening libraries and other formatting options, please, refer to the full collection of Coronavirus Screening Libraries.

Pre-plated Cysteine Focused Covalent Inhibitor Library

3,200 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-CovInh-1

3200

10 mM

DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-CovInh-2

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Cysteine Focused Covalent Inhibitor Library.

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-Protease-1

3200

10 mM

DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-Protease-2

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate;

1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Cysteine Protease Focused Library.

Pre-plated Fragment Diversity Sets

Novel Fragment Diversity Subsets of 1,280, 960 and 320 drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.

These diversity sets are fully customizable and can be delivered in any concentration and volume (for example, concentration 50/100/150/200 mM and solution volume 10/20/50/100 uL).

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Fragment Diversity Subsets with Experimental Solubility.

Pre-plated Fsp3 Screening Set

10,560 Fsp3-enriched screening compounds with average Fsp3 count 0.56 (cut-off ≥0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house MedChem filters.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Fsp3-Set-1

10560

10 mM

DMSO solution

5/10/20/25/50 uL

33

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Fsp3-Set-2

10560

10 mM

DMSO solution

100 uL

132

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Fsp³-enriched Screening Compound Library.

Pre-plated Helicase Focused Library

2,531 drug-like screening compounds with potential helicase-related activity for drug discovery in areas of infectious diseases and cancer.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Helicase-1

2531

10 mM DMSO solution

5/10/20/25/50 uL

8

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Helicase-2

2531

10 mM DMSO solution

100 uL

32

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For a detailed description and other formatting options, please, refer to the full Helicase Focused Library.

Pre-plated RNA Screening Library

3,300 drug-like compounds with predicted RNA interaction activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

RNA-Lib-1

3300

10 mM DMSO solution

5/10/20/25/50 uL

10

384-well microplate, 352 compounds per plate; 23, 24 columns empty

RNA-Lib-2

3300

10 mM DMSO solution

100 uL

38

96-well microplate, 88 compounds per plate; 12 column empty

 For a detailed description and other formatting options, please, refer to the full RNA Targeted Library.

Pre-plated Soluble Fluorine-containing Fragment Set

1,350 fluorine-containing fragments with experimentally assured solubility at 200 mM in the DMSO solution. This screening compound collection can be used as readily-available fluorine fragment cocktails for FBDD research projects.

 Download the full list of compounds (SD File) here.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Solub-Fluor-1

1350

10 mM DMSO-d6 solution

25/50/100 uL

17

96-well microplate, 80 compounds per plate; 1, 12 columns empty

For details about solubility measurements in DMSO and PBS as well as more fluorinated fragment-like compounds, refer to our collection of related products:

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