Pre-plated Focused Libraries

Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

• Pre-plated Fragment Diversity Sets
• Pre-plated Bioactive Compound Library
• Pre-plated Fsp³ Screening Set
• Pre-plated Cysteine Protease Focused Library
• Pre-plated Cysteine Focused Covalent Inhibitor Library
• Pre-plated ATPase Focused Set

Key features:

• Novel screening compounds synthesized in-house
• Several formatting options available
• Competitive pricing and convenient terms
• Application of rigorous drug-likeness filters
• Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
• Guaranteed hit re-supply, product scale-up

Please, contact us at orders@lifechemicals.com for details and price quotations.

Pre-plated Fragment Diversity Sets

Novel Fragment Diversity Subsets of 960 (Subset 1) and 320 (Subset 2) drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.

Several formatting options are available on request (such as varied concentration 50/100/150/200 mM and solution volume 20/50/100 uL).

For more details and formatting options, please, refer to the Fragment Diversity Subsets with Experimental Solubility.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

For more details and other formatting options please refer to the Biologically Active Compound Library.

Pre-plated Fsp³ Screening Set

10,560 Fsp³-enriched screening compounds with average Fsp³ count 0.56 (cut-off ≥ 0.45) and 0.87 similarity (Tanimoto). The average values of physicochemical parameters and compound distribution by Fsp³ are shown in Fig. 1-2. Compounds with unwanted moieties were filtered out with PAINS and in-house medchem filters.

For more details and other formatting options, please, refer to the Fsp³-enriched Screening Compound Library.

Fig. 1. Average physicochemical parameter values for the Pre-plated Fsp³ Screening Library

Fig. 2. Compound distribution by Fsp³ value in the Pre-plated Fsp³ Screening Library

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

For more details and other formatting options, please, refer to the Cysteine Protease Focused Library.

Pre-plated Cysteine Focused Covalent Inhibitor Library

1,300 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

For more details and other formatting options, please, refer to the Cysteine Focused Covalent Inhibitor Library.

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

For more details and other formatting options, please, refer to the ATPase Focused Libraries.