Pre-plated Focused Libraries

Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

• Pre-plated ATPase Focused Set
• Pre-plated Bioactive Compound Library
• Pre-plated CNS Screening Library
• Pre-plated Coronavirus COVID-19 Screening Set
• Pre-plated Cysteine Focused Covalent Inhibitor Library
• Pre-plated Cysteine Protease Focused Library
• Pre-plated Fragment Diversity Sets
• Pre-plated Fsp³ Screening Set
• Pre-plated Helicase Focused Library
• Pre-plated Kinase Diversity Screening Set
• Pre-plated PPI-focused Screening Set
• Pre-plated RNA Screening Library
• Pre-plated Soluble Fluorine-containing Fragment Set

Key features

• Novel screening compounds synthesized in-house
• Several formatting options available in 384- or 96-well microplates
• Competitive pricing and convenient terms
• Application of rigorous drug-likeness filters
• Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
• Guaranteed hit re-supply, product scale-up

Formatting

• 384-well PP-masterblocks, Greiner bio-one ref: 781280 or 784201, V-bottom microtiter plate
• 96-well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0 ml microplate capped with capmats, Greiner bio-one ref.# 381070
• 96-well plates, Matrix cat.# 4247, racked round-bottom tubes, 1.4 ml capped tubes with cap-strips cat.#4413 or cap-mats cat.# 4430

Please, contact us at orders@lifechemicals.com for any additional information and price quotations.

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full ATPase Focused Libraries.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the full Biologically Active Compound Library.

Pre-plated CNS Screening Library

7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full CNS Screening Library.

Pre-plated Coronavirus COVID-19 Screening Set

2,300 drug-like screening compounds to facilitate anti-coronavirus drug discovery projects.

 Download the full list of compounds (SD File) here.

For a detailed description of different coronavirus-related screening libraries and other formatting options, please, refer to the full collection of Coronavirus Screening Libraries.

Pre-plated Cysteine Focused Covalent Inhibitor Library

3,200 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Cysteine Focused Covalent Inhibitor Library.

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Cysteine Protease Focused Library.

Pre-plated Fragment Diversity Sets

Novel Fragment Diversity Subsets of 1,280, 960 and 320 drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.

These diversity sets are fully customizable and can be delivered in any concentration and volume (for example, concentration 50/100/150/200 mM and solution volume 10/20/50/100 uL).

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Fragment Diversity Subsets with Experimental Solubility.

Pre-plated Fsp³ Screening Set

10,560 Fsp³-enriched screening compounds with average Fsp³ count 0.56 (cut-off ≥0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house MedChem filters.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Fsp³-enriched Screening Compound Library.

Pre-plated Helicase Focused Library

2,531 drug-like screening compounds with potential helicase-related activity for drug discovery in areas of infectious diseases and cancer.

 Download the full list of compounds (SD File) here.

Pre-plated Kinase Diversity Screening Set

2,000 potential small-molecule kinase inhibitors with optimal physicochemical properties and maximal diversity for immunology and cancer-related drug discovery.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the Protein Kinase Diversity Set.

Pre-plated PPI-focused Screening Set

6,080 small-molecule potential PPI binders, selected based on proprietary PPI Focused Library by Machine Learning (Decision Tree) Method.

Download the full list of compounds (SD File) here. 

For a detailed description and other formatting options, please, refer to our collection of related Protein-Protein Interaction Screening Libraries:

• PPI Focused Libraries by Ligand-based Approach
• PPI Targeted Libraries by Receptor-based Approach
• PD-L1 Targeted Screening Library

Pre-plated RNA Screening Library

3,300 drug-like compounds with predicted RNA interaction activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the full RNA Targeted Library.

Pre-plated Soluble Fluorine-containing Fragment Set

1,350 fluorine-containing fragments with experimentally assured solubility at 200 mM in the DMSO solution. This screening compound collection can be used as readily-available fluorine fragment cocktails for FBDD research projects.

 Download the full list of compounds (SD File) here.

For details about solubility measurements in DMSO and PBS as well as more fluorinated fragment-like compounds, refer to our collection of related products:

• Fragment Library with Experimental Solubility
• Fluorine Fragment Library
• Fluorine Fragment Cocktails