Pre-plated Focused Libraries

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Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

Key features:

  • Novel screening compounds synthesized in-house
  • Several formatting options available
  • Competitive pricing and convenient terms
  • Application of rigorous drug-likeness filters
  • Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
  • Guaranteed hit re-supply, product scale-up

Please, contact us at orders@lifechemicals.com for details and price quotations.

Pre-plated Fragment Diversity Sets

Novel Fragment Diversity Subsets of 1,280, 960 and 320 drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.

These diversity sets are fully customizable and can be delivered in any concentration and volume (for example, concentration 50/100/150/200 mM and solution volume 20/50/100 uL)

For more details and formatting options, please, refer to the Fragment Diversity Subsets with Experimental Solubility.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

For more details and other formatting options please refer to the Biologically Active Compound Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Bioactive-1

8000

10 mM

DMSO solution

50 uL

25

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

 

Pre-plated CNS Screening Library

7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals. For more details and other formatting options please refer to the CNS Screening Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

CNS-Set-1

7100

10 mM

DMSO solution

50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

CNS-Set-2

7100

10 mM

DMSO solution

100 uL

89

96-well microplate, 80 compounds per plate; 1, 12 columns empty


Pre-plated Fsp3 Screening Set

10,560 Fsp3-enriched screening compounds with average Fsp3 count 0.56 (cut-off 0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house medchem filters.

For more details and other formatting options, please, refer to the Fsp³-enriched Screening Compound Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Fsp3-Set-1

10560

10 mM

DMSO solution

50 uL

33

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Fsp3-Set-2

10560

10 mM

DMSO solution

100 uL

132

96-well microplate, 80 compounds per plate; 1, 12 columns empty

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

For more details and other formatting options, please, refer to the Cysteine Protease Focused Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-Protease-1

3200

10 mM

DMSO solution

20 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-Protease-2

3200

10 mM

DMSO solution

50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-Protease-3

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate;

1, 12 columns empty

Pre-plated Cysteine Focused Covalent Inhibitor Library

3,200 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

For more details and other formatting options, please, refer to the Cysteine Focused Covalent Inhibitor Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

Cys-CovInh-1

3200

10 mM

DMSO solution

50 uL

10

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

Cys-CovInh-2

3200

10 mM

DMSO solution

100 uL

40

96-well microplate, 80 compounds per plate; 1, 12 columns empty

Pre-plated RNA Screening Library

3,300 drug-like compounds with predicted RNA interaction activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

For more details and other formatting options, please, refer to the RNA Targeted Library.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

RNA-Lib-1

3300

10 mM DMSO solution

50 uL

10

384-well microplate, 352 compounds per plate; 23, 24 columns empty

RNA-Lib-2

3300

10 mM DMSO solution

100 uL

38

96-well microplate, 88 compounds per plate; 12 column empty

 

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

For more details and other formatting options, please, refer to the ATPase Focused Libraries.

Catalog ID

Compounds

Concentration

Volume

Plates

Format

ATPase-1

7300

10 mM

DMSO solution

20 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

ATPase-2

7300

10 mM

DMSO solution

50 uL

23

384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty

ATPase-3

7300

10 mM

DMSO solution

60 uL

92

96-well microplate, 80 compounds per plate;
1, 12 columns empty

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