Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):
Key features:
- Novel screening compounds synthesized in-house
- Several formatting options available
- Competitive pricing and convenient terms
- Application of rigorous drug-likeness filters
- Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
- Guaranteed hit re-supply, product scale-up
Please, contact us at orders@lifechemicals.com for details and price quotations.
Pre-plated ATPase Focused Set
7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.
For more details and other formatting options, please, refer to the ATPase Focused Libraries.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
ATPase-1 |
7300 |
10 mM DMSO solution |
20 uL |
23 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
ATPase-2 |
7300 |
10 mM DMSO solution |
50 uL |
23 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
ATPase-3 |
7300 |
10 mM DMSO solution |
60 uL |
92 |
96-well microplate, 80 compounds per plate; |
Pre-plated Bioactive Compound Library
8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.
For more details and other formatting options please refer to the Biologically Active Compound Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
Bioactive-1 |
8000 |
10 mM DMSO solution |
50 uL |
25 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Pre-plated CNS Screening Library
7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals. For more details and other formatting options please refer to the CNS Screening Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
CNS-Set-1 |
7100 |
10 mM DMSO solution |
50 uL |
23 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
CNS-Set-2 |
7100 |
10 mM DMSO solution |
100 uL |
89 |
96-well microplate, 80 compounds per plate; 1, 12 columns empty |
Pre-plated Cysteine Focused Covalent Inhibitor Library
3,200 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.
For more details and other formatting options, please, refer to the Cysteine Focused Covalent Inhibitor Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
Cys-CovInh-1 |
3200 |
10 mM DMSO solution |
50 uL |
10 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Cys-CovInh-2 |
3200 |
10 mM DMSO solution |
100 uL |
40 |
96-well microplate, 80 compounds per plate; 1, 12 columns empty |
Pre-plated Cysteine Protease Focused Library
3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.
For more details and other formatting options, please, refer to the Cysteine Protease Focused Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
Cys-Protease-1 |
3200 |
10 mM DMSO solution |
20 uL |
10 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Cys-Protease-2 |
3200 |
10 mM DMSO solution |
50 uL |
10 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Cys-Protease-3 |
3200 |
10 mM DMSO solution |
100 uL |
40 |
96-well microplate, 80 compounds per plate; 1, 12 columns empty |
Pre-plated Fragment Diversity Sets
Novel Fragment Diversity Subsets of 1,280, 960 and 320 drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.
These diversity sets are fully customizable and can be delivered in any concentration and volume (for example, concentration 50/100/150/200 mM and solution volume 20/50/100 uL)
For more details and formatting options, please, refer to the Fragment Diversity Subsets with Experimental Solubility.
Pre-plated Fsp3 Screening Set
10,560 Fsp3-enriched screening compounds with average Fsp3 count 0.56 (cut-off ≥ 0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house medchem filters.
For more details and other formatting options, please, refer to the Fsp³-enriched Screening Compound Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
Fsp3-Set-1 |
10560 |
10 mM DMSO solution |
50 uL |
33 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Fsp3-Set-2 |
10560 |
10 mM DMSO solution |
100 uL |
132 |
96-well microplate, 80 compounds per plate; 1, 12 columns empty |
Pre-plated Helicase Focused Library
2,531 drug-like screening compounds with potential helicase-related activity for drug discovery in areas of infectious diseases and cancer.
For more details and other formatting options, please, refer to the Helicase Focused Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
Helicase-1 |
2531 |
10 mM DMSO solution |
50 uL |
8 |
384-well microplate, 320 compounds per plate; 1, 2, 23, 24 columns empty |
Helicase-2 |
2531 |
10 mM DMSO solution |
100 uL |
32 |
96-well microplate, 80 compounds per plate; 1, 12 columns empty |
Pre-plated RNA Screening Library
3,300 drug-like compounds with predicted RNA interaction activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.
For more details and other formatting options, please, refer to the RNA Targeted Library.
Catalog ID |
Compounds |
Concentration |
Volume |
Plates |
Format |
RNA-Lib-1 |
3300 |
10 mM DMSO solution |
50 uL |
10 |
384-well microplate, 352 compounds per plate; 23, 24 columns empty |
RNA-Lib-2 |
3300 |
10 mM DMSO solution |
100 uL |
38 |
96-well microplate, 88 compounds per plate; 12 column empty |