Preplated Focused Libraries

Life Chemicals offers a number of Pre-plated Focused Libraries for the identification of hit compounds via high throughput screening (HTS) and high content screening (HCS):

• Pre-plated 3D-shaped Screening Sets
• Pre-plated Antibacterial Screening Library
• Pre-plated ATPase Focused Set
• Pre-plated Bioactive Compound Library
• Pre-plated CNS Screening Library
• Pre-plated Coronavirus COVID-19 Screening Set
• Pre-plated Cysteine Focused Covalent Inhibitor Library
• Pre-plated Cysteine Protease Focused Library
• Pre-plated Fsp³ Screening Set
• Pre-plated Helicase Focused Library
• Pre-plated Kinase Diversity Screening Set
• Pre-plated PI3K/Akt/mTOR Screening Set
• Pre-plated PPI-focused Screening Set
• Pre-plated RNA Screening Library

Please, contact us at orders@lifechemicals.com for any additional information and price quotations.

Key features

• Novel screening compounds synthesized in-house
• Several formatting options available in 384- or 96-well microplates
• Competitive pricing and convenient terms
• Application of rigorous drug-likeness filters
• Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
• Guaranteed hit re-supply, product scale-up
• Compound library design and combinatorial synthesis based on found hits

Formatting

• 384-well PP-masterblocks, Greiner bio-one ref: 781280 or 784201, V-bottom microtiter plate
• 96-well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0 ml microplate capped with capmats, Greiner bio-one ref.# 381070
• 96-well plates, Matrix cat.# 4247, racked round-bottom tubes, 1.4 ml capped tubes with cap-strips cat.#4413 or cap-mats cat.# 4430

Pre-plated 3D-shaped Screening Sets

22,765 3D-like sp3-rich screening compounds as an efficient starting point for both phenotypic and target-based HTS in drug discovery projects. Alternatively, two smaller complementary and non-overlapping subsets of 18,520 and 4,245 non-planar molecules are also purchasable separately in the pre-plated format.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full collection of 3D Compound Libraries for HTS. You can also be interested in our related products:

• 3D-shaped Fragment Library
• Fsp³-enriched Screening Compound Library
• Fsp³-enriched Fragment Library

Pre-plated Antibacterial Screening Library

10,880 drug-like screening compounds with potential antibacterial activity against different gram-positive and gram-negative bacteria species and bacteria-related protein targets, selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Antibacterial Screening Compound Library.

Pre-plated ATPase Focused Set

7,300 drug-like screening compounds with potential ATPase inhibiting activity selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full ATPase Focused Libraries.

Pre-plated Bioactive Compound Library

8,000 structurally diverse screening compounds with confirmed biological activity against about 600 biological targets of pharmaceutical interest.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the full Biologically Active Compound Library.

Pre-plated CNS Screening Library

7,100 structurally diverse screening compounds with properties favorable for BBB-penetration aimed for drug development of CNS-active pharmaceuticals.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full CNS Screening Library.

Pre-plated Coronavirus COVID-19 Screening Set

2,300 drug-like screening compounds from 2019-nCoV Main Protease Targeted Library to facilitate anti-coronavirus drug discovery projects.

 Download the full list of compounds (SD File) here.

For a detailed description of different coronavirus-related screening libraries and other formatting options, please, refer to the full collection of Coronavirus Screening Libraries.

Pre-plated Cysteine Focused Covalent Inhibitor Library

3,200 potential cysteine covalent binders containing Cys-focused covalent warheads selected with machine learning methods (e.g., covalent fingerprints) and diversity filtering.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Cysteine Focused Covalent Inhibitor Library.

Pre-plated Cysteine Protease Focused Library

3,200 drug-like screening compounds with potential inhibitory activity against cysteine proteases selected with 2D fingerprint similarity.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Cysteine Protease Focused Library.

Pre-plated Fsp³ Screening Set

10,560 Fsp³-enriched screening compounds with average Fsp³ count 0.56 (cut-off ≥0.45) and 0.87 similarity (Tanimoto). Compounds with unwanted moieties were filtered out with PAINS and in-house MedChem filters.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Fsp³-enriched Screening Compound Library.

Pre-plated Helicase Focused Library

2,531 drug-like screening compounds with potential helicase-related activity for drug discovery in areas of infectious diseases and cancer.

 Download the full list of compounds (SD File) here.

For a detailed description and other formatting options, please, refer to the full Helicase Focused Library.

Pre-plated Kinase Diversity Screening Set

2,000 potential small-molecule kinase inhibitors with optimal physicochemical properties and maximal diversity for immunology and cancer-related drug discovery.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the Protein Kinase Diversity Set.

Pre-plated PI3K/Akt/mTOR Screening Set

4,427 small-molecule screening compounds with potential inhibitory activity against the PI3K/Akt/mTOR pathway, aimed for anticancer drug discovery.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the PI3K/Akt/mTOR Focused Library.

Pre-plated PPI-focused Screening Set

6,080 small-molecule potential PPI binders, selected based on proprietary PPI Focused Library by Machine Learning (Decision Tree) Method.

Download the full list of compounds (SD File) here. 

For a detailed description and other formatting options, please, refer to our collection of related Protein-Protein Interaction Screening Libraries:

• PPI Focused Libraries by Ligand-based Approach
• PPI Targeted Libraries by Receptor-based Approach

Pre-plated RNA Screening Library

3,300 drug-like compounds with predicted RNA interaction activity for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.

 Download the full list of compounds (SD File) here.

 For a detailed description and other formatting options, please, refer to the full RNA Targeted Library.