Building Blocks

Life Chemicals performs the design and synthesis of advanced chemical building blocks: small molecules (scaffolds, chemical intermediates, and fine reagents) bearing various reactive functional groups that allow introducing certain structural motifs into the desired final products.

Their structures are mostly based on rare chemotypes with favorable physicochemical parameters, thus being excellent decorators in the combinatorial synthesis of compound libraries and promising reagents for medicinal chemistry and drug design.

Our proprietary collection currently comprises more than 62,000 building blocks, including 11,000 in-stock compounds in multigram quantities. Over 50,000 tangible molecules can be synthesized within a 3-6 week timeframe, employing our in-house validated synthetic procedures. Compound re-synthesis and scale-up (up to 50 kg) are provided on request.

All our building blocks undergo quality control to elucidate their chemical structures and guarantee their purity of > 95 %, confirmed with 400MHz NMR and/or LCMS.

 

Explore and purchase our building blocks via our online shop! There you can check compound availability, current prices and lead time information. The compounds can be searched by CAS, catalog number, substructure or similarity.

Feel free to contact us directly at orders@lifechemicals.com to get additional information, discuss your specific requirements, request our analogue search service or place a purchase order.

 

Examples of offered chemical classes include:

Alcohols, thiols

Alcohols, thiols

 

Amines: primary and secondary

Amines: primary and secondary

 

Aldehydes, ketones

Aldehydes, ketones

 

Carboxylic acids, amino acids, boronic acids and their esters

Carboxylic acids, amino acids, boronic acids and their esters

 

Sulphonyl and acyl halides

Sulphonyl and acyl halides

 

Alkyl and aryl halides, fluorinated compounds

Alkyl and aryl halides, fluorinated compounds

 

Alkynes, nitriles, isocyanates, azides

Alkynes, nitriles, isocyanates, azides

 

Bicyclic compounds: spiro, fused, bridged

Bicyclic compounds: spiro, fused, bridged

 

Small carbo- and hetero-cycles: cyclopropanes, cyclobutanes, epoxides, azetidines, oxetanes

Small carbo- and hetero-cycles: cyclopropanes, cyclobutanes, epoxides, azetidines, oxetanes

 

Functionalized saturated heterocycles: piperidines, morpholines, piperazines, pyrrolidines, tetrahydrofurans, tetrahydropyrans, etc.

Functionalized saturated heterocycles: piperidines, morpholines, piperazines, pyrrolidines, tetrahydrofurans, tetrahydropyrans, etc.

 

Functionalized aromatic heterocycles: pyridines, diazines (pyrazines, pyrimidines, pyridazine), pyrazoles, azoles (imidazoles, oxazoles, thiazoles, triazoles), etc.

Functionalized aromatic heterocycles: pyridines, diazines (pyrazines, pyrimidines, pyridazine), pyrazoles, azoles (imidazoles, oxazoles, thiazoles, triazoles), etc.