Life Chemicals performs the design and synthesis of advanced chemical building blocks: small molecules (scaffolds, chemical intermediates, and fine reagents) bearing various reactive functional groups that allow introducing certain structural motifs into the desired final products.
Their structures are mostly based on rare chemotypes with favorable physicochemical parameters, thus being excellent decorators in the combinatorial synthesis of compound libraries and promising reagents for medicinal chemistry and drug design.
Our proprietary collection currently comprises more than 62,000 building blocks, including 11,000 in-stock compounds in multigram quantities. Over 50,000 tangible molecules can be synthesized within a 3-6 week timeframe, employing our in-house validated synthetic procedures. Compound re-synthesis and scale-up (up to 50 kg) are provided on request.
All our building blocks undergo quality control to elucidate their chemical structures and guarantee their purity of > 95 %, confirmed with 400MHz NMR and/or LCMS.
Explore and purchase our building blocks via our online shop! There you can check compound availability, current prices and lead time information. The compounds can be searched by CAS, catalog number, substructure or similarity.
Examples of offered chemical classes include:
Amines: primary and secondary
Carboxylic acids, amino acids, boronic acids and their esters
Sulphonyl and acyl halides
Alkyl and aryl halides, fluorinated compounds
Alkynes, nitriles, isocyanates, azides
Bicyclic compounds: spiro, fused, bridged
Small carbo- and hetero-cycles: cyclopropanes, cyclobutanes, epoxides, azetidines, oxetanes
Functionalized saturated heterocycles: piperidines, morpholines, piperazines, pyrrolidines, tetrahydrofurans, tetrahydropyrans, etc.
Functionalized aromatic heterocycles: pyridines, diazines (pyrazines, pyrimidines, pyridazine), pyrazoles, azoles (imidazoles, oxazoles, thiazoles, triazoles), etc.