Life Chemicals proficient team specializing in cutting-edge fine chemistry dynamically and successfully designs and synthesizes advanced chemical building blocks: small molecules (scaffolds, chemical intermediates, and fine reagents) bearing various reactive functional groups that allow the introduction of chemical diversity and specific structural motifs into the target molecules.
The reagent structures are mostly based on novel and rare chemotypes with favorable physicochemical parameters, thus being excellent decorators in the combinatorial synthesis of compound libraries and promising reagents for organic synthesis, medicinal chemistry and drug discovery.
Our proprietary Chemical Building Block Collection currently comprises more than 63,000 building blocks, including 13,000 in-stock compounds in multigram quantities.
Examples of chemical classes to be offered include:
Over 50,000 tangible molecules can be synthesized within a 3-6 week timeframe, employing our in-house validated synthetic procedures. Compound re-synthesis and scale-up (up to 50 kg) are provided on request.
Feel free to contact us directly at orders@lifechemicals.com to get additional information, discuss your specific requirements, or place a purchase order.
Explore and purchase our building blocks via our online shop! There you can check compound availability, current prices, and lead time information. The compounds can be searched by CAS, catalog number, substructure, or similarity.
Further reading is available in our MedChem blog dedicated to Building Blocks and Custom synthesis.
Key Features:
- All compounds are synthesized in-house
- Most chemical building blocks are available from stock in 0.25-10 g amounts via fast on-line purchase from our e-commerce website
- Every building block undergoes thorough quality control to elucidate its chemical structure
- Purity of over 95 % is confirmed with 400MHz NMR and/or LCMS
- As a contract research organization (CRO), Life Chemicals also provides custom synthesis services to produce small-molecule compounds as per the customer’s specifications
- Our state-of-the-art synthetic capacities and skillful chemistry enable us to add over 25,000 novel organic compounds (both screening compounds and building blocks) to our product catalog annually
Chemically-diverse building blocks are used to functionalize drug-like compounds in hit-to-lead and lead-optimization projects to facilitate SAR exploration, as well as modulate and fine-tune the physicochemical properties (such as, increased solubility or improved metabolic stability).
New selected building blocks as examples to illustrate the collection diversity
Please click on the compound class name to perform a search on our e-shop. The result with the most updated compound availability will be shown. You can download the search results and order compounds after the website login/registration.
Alcohols, thiols
Amines: primary and secondary
Aldehydes, ketones
Carboxylic acids, amino acids, boronic acids and their esters
Sulphonyl and acyl halides
Alkyl and aryl halides
Fluorinated compounds
Alkynes, nitriles, isocyanates, azides
Bicyclic compounds: spiro, fused, bridged
Small carbo- and hetero-cycles: cyclopropanes, cyclobutanes, epoxides, azetidines, oxetanes
Functionalized saturated heterocycles: piperidines, morpholines, piperazines, pyrrolidines, tetrahydrofurans, tetrahydropyrans, etc.
Functionalized aromatic heterocycles: pyridines, diazines (pyrazines, pyrimidines, pyridazine), pyrazoles, azoles (imidazoles, oxazoles, thiazoles, triazoles), etc.
