Life Chemicals offers several Fragment Screening Sets as convenient and efficient starting point for fragment-based approach to drug discovery (FBDD) projects.
Please, contact us at orders@lifechemicals.com for any additional information and price quotations.
Key features
- Novel fragment-like screening compounds synthesized in-house
- Ideal for fragment-based lead generation
- Several formatting options available in 384- or 96-well microplates
- Competitive pricing and convenient terms
- Application of rigorous drug-likeness filters
- Assured ≥ 90 % purity confirmed by LCMS and/or NMR data
- Guaranteed hit re-supply, product scale-up
- Compound library design and combinatorial synthesis based on found hits
Formatting
- 384-well PP-masterblocks, Greiner bio-one ref: 781280 or 784201, V-bottom microtiter plate
- 96-well PP-masterblocks, Greiner bio-one ref: 780215, U-bottom 1.0 ml microplate capped with capmats, Greiner bio-one ref.# 381070
- 96-well plates, Matrix cat.# 4247, racked round-bottom tubes, 1.4 ml capped tubes with cap-strips cat.#4413 or cap-mats cat.# 4430
Pre-plated Covalent Fragment Screening Set
5,704 covalent inhibitor fragments, containing covalent warheads, for efficient covalent fragment screening. Purchasable as one big screening set or, alternatively, as four smaller complementary and non-overlapping subsets, selected to provide optimal structural diversity: 2,824, 1,600, 960 and 320 fragment-like covalent inhibitors.
High quality of the screening pulls: all non-selective covalent binders containing highly reactive electrophilic and nucleophilic groups, as well as compounds with non drug-like cores, were excluded from this screening library.
These Covalent Fragment Screening Sets are fully customizable and can be delivered in several concentration and volume (for example, concentration 100/50 mM and solution volume 100/50/20/10 uL) in either 96- or 384-well plates.
Download the full list of compounds (SD File) here.
For a detailed description and other formatting options, please, refer to the full Covalent Fragment Library. You can also be interested in the related Covalent Inhibitor Screening Libraries.
Pre-plated Fragment Diversity Sets
Novel Fragment Diversity Subsets of 1,280, 960 and 320 drug-like fragments with experimentally assured solubility at 200 mM in the DMSO solution. The sets are efficient starting kits for FBDD research projects.
These Diversity Screening Sets are fully customizable and can be delivered in several concentration and volume (for example, concentration 200/150/100/50 mM and solution volume 100/50/20/10 uL).
Download the full list of compounds (SD File) here.
For a detailed description and other formatting options, please, refer to the full Fragment Diversity Subsets with Experimental Solubility