Life Chemicals offers its Bioactive Screening Compound Library of over 8,000 drug-like small molecules as a perfect starting point for phenotypic (cell-based) and target-based high throughput screening (HTS) drug discovery research projects.
The selected structurally diverse bioactive molecules have been tested in functional, binding and other biological assays and have confirmed bioactivity in vitro and/or in vivo against about 600 biological targets of pharmaceutical interest.
The Library has been designed on the basis of the ChEMBL database (v25) which contained:
- 1,929,473 compound records
- 1,592,191 compounds
- 13,968,617 activities
- 1,212,831 assays
- 11,019 targets
This Bioactive Compound Collection includes enzyme inhibitors, receptor ligands, and ion channel regulators for different targets (such as kinases, GPCRs, ion channels) and activity areas (e.g., biotechnology, epigenetics, antiviral or antibacterial research).
Each entry is supplied with a link to its Compound Report Card and Bioactivity Summary. High compound purity (> 90%) is confirmed by LCMS and/or NMR analytical data.
The activity records of the presented set of bioactive compounds meet the following criteria:
The compound selection can be customized based on your requirements, cherry-picking is available. The Advanced Subset of highly active compounds (the selection criteria: activity values < 1 µM, inhibition > 70 %) as well as focused subsets for specific target types and therapeutic areas are available on request.
A preplated set based on this Screening Library is also offered. For more details, please, consult our Pre-plated Focused Libraries.
Please, contact us at email@example.com for any additional information and price quotations.
Examples of protein targets against which compounds from the Library have shown activity are provided below: