The Life Chemicals Library of Bioactive Screening Compounds contains over 8,500 small molecules that have been tested in functional, binding and other biological assays and have confirmed bioactivity in vitro and/or in vivo against various biological targets of pharmaceutical interest. The library has been designed on the basis of the ChEMBL database which contained:
- 1,929,473 compound records
- 1,592,191 compounds
- 13,968,617 activities
- 1,212,831 assays
- 11,019 targets
Each compound is supplied with a link to its Compound Report Card and Bioactivity Summary. Given below are examples of targets against which the Library compounds have shown activity:
- 3C-like protease
- 4'-phosphopantetheinyl transferase ffp
- Acidic alpha-glucosidase
- Activin receptor type-1
- Adenosine A3 receptor
- Aldehyde dehydrogenase 1A1
- ALK tyrosine kinase receptor
- AMP-activated protein kinase, alpha-1 subunit
- Ataxin-2
- ATPase family AAA domain-containing protein 5
- Beta Lactamase
- Bone morphogenetic protein receptor type-1B
- Bone morphogenetic protein receptor type-2
- Bromodomain adjacent to zinc finger domain protein 2B
- CaM kinase II delta
- Casein kinase I epsilon
- Casein kinase I gamma 2
- Cell division protein kinase 8
- Chaperone activity of bc1 complex-like, mitochondrial
- Citron Rho-interacting kinase
- Cyclin-dependent kinase 1
- Cyclin-dependent kinase 3
- Cyclin-dependent kinase 4
- Cyclin-dependent kinase 7
- Cyclin-dependent kinase 9
- Cyclin-dependent kinase-like 3
- Cytochrome P450 2C19
- Cytochrome P450 2D6
- Death-associated protein kinase 3
- Discoidin domain-containing receptor 2
- Dual specificity mitogen-activated protein kinase 1
- Dual specificity mitogen-activated protein kinase 2
- Dual specificity mitogen-activated protein kinase 5
- Dual specificity testis-specific protein kinase 1
- Dual specificty protein kinase CLK1
- Enoyl Reductase
- Ephrin type-A receptor 1
- Ephrin type-A receptor 2
- Ephrin type-A receptor 3
- Ephrin type-A receptor 4
- Ephrin type-A receptor 5
- Ephrin type-A receptor 6
- Ephrin type-A receptor 7
- Ephrin type-A receptor 8
- Ephrin type-B receptor 1
- Ephrin type-B receptor 2
- Ephrin type-B receptor 4
- Ephrin type-B receptor 6
- Epidermal growth factor receptor erbB1
- Epithelial discoidin domain-containing receptor 1
- Eukaryotic translation initiation factor 2-alpha kinase 4
- FAD-linked sulfhydryl oxidase ALR
- Fibroblast growth factor receptor 1
- Fibroblast growth factor receptor 2
- Fibroblast growth factor receptor 3
- Fibroblast growth factor receptor 4
- G protein-coupled receptor 44
- Geminin
- Glucagon-like peptide 1 receptor
- Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
- Glycogen synthase kinase-3 beta
- Hepatocyte growth factor receptor
- HepG2
- Histone acetyltransferase GCN5
- Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
- Hormonally up-regulated neu tumor-associated kinase
- Huntingtin
- Inhibitor of nuclear factor kappa B kinase alpha subunit
- Inhibitor of nuclear factor kappa B kinase beta subunit
- Insulin receptor
- Insulin-like growth factor I receptor
- Interleukin-1 receptor-associated kinase 1
- Interleukin-1 receptor-associated kinase 4
- Isocitrate dehydrogenase [NADP] cytoplasmic
- Leukocyte tyrosine kinase receptor
- Luciferin 4-monooxygenase
- Lysine-specific demethylase 4D-like
- Macrophage colony stimulating factor receptor
- Macrophage-stimulating protein receptor
- MAP kinase p38 gamma
- MAP kinase signal-integrating kinase 2
- MAP kinase-interacting serine/threonine-protein kinase MNK1
- Methionine aminopeptidase 2
- Methionyl-tRNA synthetase, putative
- Misshapen-like kinase 1
- Mitogen-activated protein kinase 6
- Mitogen-activated protein kinase 15
- Mitogen-activated protein kinase 4
- Mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 2
- Mitogen-activated protein kinase 3
- Mitogen-activated protein kinase 4
- Mitogen-activated protein kinase 5
- Mixed lineage kinase 7
- Monoamine oxidase A
- Monoamine oxidase B
- M-phase phosphoprotein 8
- Mycobacterium bovis BCG
- Myosin light chain kinase family member 4
- Myosin-IIIB
- Nerve growth factor receptor Trk-A
- Neuropeptide S receptor
- Niemann-Pick C1 protein
- Nonstructural protein 1
- Paired box protein Pax-8Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- Phosphorylase kinase gamma subunit 1
- Phosphorylase kinase gamma subunit 2
- Plasmodium falciparum
- Platelet-derived growth factor receptor alpha
- Platelet-derived growth factor receptor beta
- Proto-oncogene tyrosine-protein kinase MER
- Putative uncharacterized protein
- Ras-related protein Rab-9A
- Receptor protein-tyrosine kinase erbB-2
- Receptor protein-tyrosine kinase erbB-4
- Receptor tyrosine-protein kinase erbB-3
- Receptor-interacting serine/threonine-protein kinase 4
- Rho-associated protein kinase 2
- Ribosomal protein S6 kinase 1
- Ribosomal protein S6 kinase alpha 1
- Ribosomal protein S6 kinase alpha 2
- Ribosomal protein S6 kinase alpha 6
- Sentrin-specific protease 6
- Sentrin-specific protease 7
- Sentrin-specific protease 8
- Serine/threonine-protein kinase 10
- Serine/threonine-protein kinase 11
- Serine/threonine-protein kinase 16
- Serine/threonine-protein kinase 2
- Serine/threonine-protein kinase 32A
- Serine/threonine-protein kinase 33
- Serine/threonine-protein kinase 35
- Serine/threonine-protein kinase AKT2
- Serine/threonine-protein kinase Aurora-C
- Serine/threonine-protein kinase Chk1
- Serine/threonine-protein kinase Chk2
- Serine/threonine-protein kinase DCLK2
- Serine/threonine-protein kinase GAK
- Serine/threonine-protein kinase MRCK beta
- Serine/threonine-protein kinase MRCK gamma
- Serine/threonine-protein kinase MRCK-A
- Serine/threonine-protein kinase PAK 4
- Serine/threonine-protein kinase PIM3
- Serine/threonine-protein kinase PLK4
- Serine/threonine-protein kinase receptor R3
- Serine/threonine-protein kinase RIPK2
- Serine/threonine-protein kinase SBK1
- Serine/threonine-protein kinase SIK1
- Serine/threonine-protein kinase SIK2
- Serine/threonine-protein kinase SIK3
- Serine/threonine-protein kinase SRPK2
- Serine/threonine-protein kinase TNNI3K
- Serine/threonine-protein kinase tousled-like 2
- Serine/threonine-protein kinase ULK3
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Serotonin transporter
- Short transient receptor potential channel 4
- Sigma opioid receptor
- Solute carrier organic anion transporter family member 1B1
- Solute carrier organic anion transporter family member 1B3
- Sphingomyelin phosphodiesterase
- SPS1/STE20-related protein kinase YSK4
- Stem cell growth factor receptor
- Survival motor neuron protein
- Thioredoxin glutathione reductase
- Thioredoxin reductase 1, cytoplasmic
- Thymidine phosphorylase
- TRAF2- and NCK-interacting kinase
- Tubulin
- Tubulin alpha-1 chain
- Tyrosine kinase non-receptor protein 2
- Tyrosine-protein kinase ABL
- Tyrosine-protein kinase ABL2
- Tyrosine-protein kinase BLK
- Tyrosine-protein kinase BRK
- Tyrosine-protein kinase BTK
- Tyrosine-protein kinase CSK
- Tyrosine-protein kinase FGR
- Tyrosine-protein kinase FRK
- Tyrosine-protein kinase FYN
- Tyrosine-protein kinase HCK
- Tyrosine-protein kinase JAK3
- Tyrosine-protein kinase LCK
- Tyrosine-protein kinase Lyn
- Tyrosine-protein kinase receptor FLT3
- Tyrosine-protein kinase receptor RET
- Tyrosine-protein kinase receptor Tie-1
- Tyrosine-protein kinase receptor TYRO3
- Tyrosine-protein kinase receptor UFO
- Tyrosine-protein kinase SRC
- Tyrosine-protein kinase Srms
- Tyrosine-protein kinase TIE-2
- Tyrosine-protein kinase TXK
- Tyrosine-protein kinase YES
- Uncharacterized aarF domain-containing protein kinase 4
- Vascular endothelial growth factor receptor
- Vascular endothelial growth factor receptor 1
- Vascular endothelial growth factor receptor 2
- Vascular endothelial growth factor receptor 3
- Voltage-gated T-type calcium channel alpha-1H subunit