Phenotypic (cell-based) and target-based high-throughput screening (HTS) drug discovery projects do need a perfect starting point! Our Bioactive Screening Compound Library of over 24,200 drug-like small molecules is undoubtedly the collection to solve this task!
The selected structurally diverse bioactive molecules have been tested in functional, binding and other biological assays and shown confirmed bioactivity in vitro and/or in vivo against over 600 unique biological targets of pharmaceutical interest.
Our biologically relevant compound collection includes enzyme inhibitors, receptor ligands and ion channel regulators for diverse molecular targets (such as kinases, GPCRs, and ion channels), and also application areas (e.g., biotechnology, epigenetics, antiviral or antibacterial research). It has already proven its practical value in screening against complex biological targets, unclassified proteins and enzymes.
You can find detailed information on Target Profiling and Biological Coverage, as well as Compound Selection Criteria and Activity Profiling, in the corresponding sections below. Every screening compound entry in the SDF file includes calculated physicochemical properties along with information on reported activity.
In addition, an Advanced Bioactive Screening Subset of highly active compounds (selection criteria: activity values < 1 µM and inhibition > 70%) and various focused subsets for specific target types and therapeutic areas can be prepared on request.
The compound selection can be customized based on your requirements, cherry-picking is available.
Please, contact us at orders@lifechemicals.com for any additional information and price quotations.
For a pre plated set based on this Screening Library, please explore our Pre-plated Focused Libraries.
Further exploring our related products will make your search even more rewarding:
Representative compounds from the Advanced set of the Bioactive Screening Compound Library
Target Profiling and Biological Coverage
Our Bioactive Screening Compound Library demonstrates broad activity across clinically relevant target classes, spanning enzymes, receptors, epigenetic regulators, transporters, transcription factors and pathogen-derived proteins. The comprehensive list of protein targets against which compounds from the proprietary screening collection have demonstrated activity is provided below.
Therapeutically irrelevant entities have been removed, ensuring a curated collection suitable for drug discovery programs in oncology, CNS disorders, inflammation, metabolism and infectious diseases.
- Enzymes & Metabolic Targets involved in central metabolism, redox biology, lipid processing and inflammatory pathways. Representative targets include dehydrogenases (DHFR, IDH), fatty acid synthase (FASN), lipoxygenases, metalloproteinases (MMPs), caspases and leukotriene A4 hydrolase.
- Kinases & Phosphatases as key regulators of cell signaling, proliferation and oncogenic transformation. Representative targets include CDK2/7, Aurora kinases, EGFR, ABL1, BRAF, PI3K, ATM/ATR and protein tyrosine phosphatases.
- G Protein–Coupled Receptors (GPCRs) involved in neurotransmission, cardiovascular regulation, immune signaling and metabolic control. Representative targets include dopamine and serotonin receptors, adrenergic receptors, muscarinic receptors, cannabinoid receptors and GLP-1 receptors.
- Nuclear Receptors & Transcriptional Regulators as key modulators of gene expression in endocrine, metabolic and oncogenic pathways. Representative targets include PPARs, estrogen and androgen receptors, glucocorticoid receptors, RORγ, STAT3 and HIF-1α.
- Epigenetic Targets: chromatin-modifying enzymes and transcriptional regulators involved in gene expression control. Representative targets include HDACs, HATs (p300, KAT2A), bromodomain proteins (BRD2/3/4), LSD1 and PRMT5.
- Transporters & Ion Channels: proteins regulating cellular transport, ion flux and multidrug resistance. Representative targets include ABC transporters (ABCB1, ABCG2), SLC family transporters, potassium channels and TRP channels.
- DNA, RNA & Genome Maintenance Targets: enzymes involved in genome stability, replication, repair and transcription. Representative targets include PARP1, DNA-PK, RAD51, WRN helicase, topoisomerase I and DNMT1.
- Protein-Protein Interaction Targets: key regulatory complexes involved in apoptosis, signaling and transcriptional control. Representative targets include BCL-2 family proteins, the MDM2–p53 axis, the KEAP1–NRF2 system and the SMAD complexes.
- Infectious Disease Targets from bacterial, viral and parasitic organisms relevant to anti-infective drug discovery. Representative targets include HIV protease, integrase and reverse transcriptase, DNA gyrase, falcipain-3 and plasmepsins.
Figure 1. Examples of inhibition of proteins involved in important cellular processes by screening compounds from the Life Chemicals Bioactive Compound Library.
Compound Selection Criteria and Activity Profiling
The Screening Library has been designed based on the ChEMBL database (v36), which contained:
- 2,878,135 compounds
- 24,267,312 annotated activities
- 1,890,749 assays
- 17,803 targets
The initial dataset was first curated automatically and manually and then the data was clustered. Every entry is supplied with a link to its Compound Report Card and Bioactivity Summary. High compound purity (> 90 %) is confirmed by LCMS and/or NMR analytical data.
The target activity records of the presented set of bioactive compounds meet the following criteria:
- Inhibition ≥ 25 %
- Ki ≤ 10 µM
- EC50 ≤ 10 µM
- CC50 ≤ 10 µM
- Kd ≤ 10 µM
- Potency ≤ 10 µM
- XC50 ≤ 10 µM
- Residual Activity ≤ 50 %
- AC50 ≤ 10 µM
- IZ > 10 mm
- MIC ≤ 10 µg/mL
- MIC ≤ 10 µM
List of Biological Targets
To sum up, our Bioactive Library provides broad and well-curated coverage of major drug discovery target classes, enabling efficient screening across multiple therapeutic areas and biological mechanisms. The list of protein targets against which the proprietary screening compounds have shown their activity is provided below:
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, 2, 4 mitochondrial
- 11-beta-hydroxysteroid dehydrogenase 1
- 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
- 17-beta-hydroxysteroid dehydrogenase type 2, 3
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
- 3',5'-cyclic-AMP phosphodiesterase 4A, 4B
- 3-hydroxyacyl-CoA dehydrogenase type-2
- 3-oxo-5-alpha-steroid 4-dehydrogenase 2
- 3-phosphoinositide-dependent protein kinase 1
- 4-aminobutyrate aminotransferase, mitochondrial
- 4'-phosphopantetheinyl transferase ffp
- 5-hydroxytryptamine receptor 1A, 1B, 2A, 2B, 2C, 3A, 3B, 6, 7
- 5'-nucleotidase
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
- 72 kDa type IV collagenase
- Aberrant Vpr protein
- Acetylcholinesterase
- ACHN
- Activated CDC42 kinase 1
- Activin receptor type-1
- Acyl-CoA desaturase 1
- Acyl-homoserine lactone acylase PvdQ
- Adenosine receptor A1, A2a, A2b, A3
- Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
- Adenylate cyclase type 1, 8
- Adrenergic receptor alpha-1, 2
- Advanced glycosylation end product-specific receptor
- AGS
- Albumin
- Alcohol dehydrogenase
- Aldehyde dehydrogenase 1A1, dimeric NADP-preferring
- Aldo-keto reductase family 1 member B1, C1, C3
- ALK tyrosine kinase receptor
- Alkaline phosphatase, germ cell type, tissue-nonspecific isozyme
- Alpha amylase
- Alpha glucosidase
- Alpha-1A, 2A adrenergic receptor
- Alpha-galactosidase A, MAL12
- Alpha-synuclein
- Alternaria alternata
- Amine oxidase [copper-containing] 3, [flavin-containing] A, B
- Amino acid transporter
- AMPK alpha2/beta1/gamma1
- Amyloid-beta precursor protein
- Androgen receptor
- Apelin receptor
- Apical membrane antigen 1
- Apoptotic protease-activating factor 1
- Aromatase
- Aryl hydrocarbon receptor
- Aspartyl aminopeptidase
- Ataxin-2
- ATPase family AAA domain-containing protein 5
- ATP-dependent 6-phosphofructokinase
- ATP-dependent Clp protease proteolytic subunit
- ATP-dependent DNA helicase Q1
- ATP-dependent molecular chaperone HSP82
- ATP-dependent translocase ABCB1
- Aurora kinase A
- Bcl-2-related protein A1
- Bcr/Abl fusion protein
- Beta Lactamase
- Beta-1, 2, 3 adrenergic receptor
- Beta-glucuronidase
- Beta-N-acetyl-D-hexosaminidase-A/B
- Beta-secretase 1
- Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Bifunctional epoxide hydrolase 2
- Bifunctional protein GlmU
- Bile acid receptor
- Botulinum neurotoxin type E
- Branched-chain-amino-acid aminotransferase, mitochondrial
- Breast cancer type 1 susceptibility protein
- Broad substrate specificity ATP-binding cassette transporter ABCG2
- Bromodomain adjacent to zinc finger domain protein 2B
- Bromodomain-containing protein 2, 3, 4, 9
- CAAX prenyl protease 1, 2
- Caco-2
- Calf thymus DNA
- cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
- Camphor 5-monooxygenase
- Cannabinoid receptor 1, 2
- Carbonic anhydrase 1, 2, 7, 9, 12, 13, 14
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
- Carnitine O-palmitoyltransferase 1, muscle isoform
- Casein kinase I isoform alpha, delta, II
- Caspase-1, 3, 6, 7
- Cathepsin B
- C-C chemokine receptor type 3, 5
- CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)
- CDGSH iron-sulfur domain-containing protein 1
- CDK8/Cyclin C
- Cellular tumor antigen p53
- cGMP-specific 3',5'-cyclic phosphodiesterase
- Chitooligosaccharidolytic beta-N-acetylglucosaminidase
- Chloride anion exchanger
- Cholesterol 24-hydroxylase
- Cholesteryl ester transfer protein
- Cholinesterase
- Chromobox protein homolog 1
- Chromodomain Y-like protein
- ClpP1P2
- Coagulation factor XII
- Cocaine esterase
- Collagenase 3
- Connector enhancer of kinase suppressor of rRas1
- Core antigen
- Cortex
- Corticotropin-releasing factor receptor 2/Corticotropin-releasing factor-binding protein
- CREB-binding protein
- Cruzipain
- Cry1/Cry2
- Cyclic nucleotide-specific phosphodiesterase
- Cyclin-dependent kinase 2, 7/cyclin H
- Cystathionine beta-lyase MetC
- Cysteine protease falcipain-3
- Cystic fibrosis transmembrane conductance regulator
- Cystine/glutamate transporter
- Cytochrome b-c1 complex subunit 7
- Cytochrome P450 1A1, 1A2, 1B1, 2A6, 2B1, 2C9, 2C19, 2D6, 3A4, 11B1, 11B2
- Cytohesin-2
- Cytokinin dehydrogenase 1
- D(1A, 2, 3, 4) dopamine receptor
- D-3-phosphoglycerate dehydrogenase
- D-alanine-D-alanine ligase B
- D-amino-acid oxidase
- dCTP pyrophosphatase 1
- Death-associated protein kinase 3
- Dehydrogenase/reductase SDR family member 9
- Delta-aminolevulinic acid dehydratase
- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
- Diacylglycerol kinase alpha
- Diacylglycerol O-acyltransferase 1
- Diamine oxidase [copper-containing]
- Dihydrofolate reductase
- Dihydrolipoyl dehydrogenase
- Dihydroorotate dehydrogenase
- Dipeptidyl peptidase 4
- DNA (cytosine-5)-methyltransferase 1
- DNA dC->dU-editing enzyme APOBEC-3A, 3F, 3G
- DNA gyrase
- DNA polymerase beta, eta, I, iota, kappa
- DNA repair nuclease/redox regulator APEX1
- DNA repair protein RAD51 homolog 1, RAD52 homolog, REV1
- DNA topoisomerase 1
- DNA-dependent protein kinase catalytic subunit
- Dopamine beta-hydroxylase
- dsDNA
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
- Dual specificity mitogen-activated protein kinase kinase 4
- Dual specificity protein kinase CLK1, CLK4
- Dual specificity protein phosphatase 1, 3, 22
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A
- Dynamin-1
- E3 ubiquitin-protein ligase Mdm2
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
- Endoplasmic rReticulum Aminopeptidase1, 2
- Endoplasmic Reticulum Chaperone BiP
- Endothelin-1 receptor
- Endothelin-converting enzyme 2
- Enoyl-acyl-carrier protein reductase
- Enteropeptidase
- Ephrin type-B receptor 4
- Epidermal growth factor receptor
- Epoxide hydrolase 1
- Epstein-Barr nuclear antigen 1
- Estrogen receptor
- Estrogen-related receptor gamma
- Eyes absent homolog 2
- FAD-linked sulfhydryl oxidase ALR
- Fascin
- Fatty acid synthase
- Fatty acid-binding protein, adipocyte, heart
- Fatty-acid amide hydrolase 1
- Ferritin light chain
- Ferroportin
- Fibroblast growth factor 22
- Fibroblast growth factor receptor 1
- Flap endonuclease 1
- FM3A
- fMet-Leu-Phe receptor
- Free fatty acid receptor 1, 2
- Fructose-1,6-bisphosphatase 1
- Fructose-bisphosphate aldolase
- G protein-coupled receptor kinase 6
- GABA transporter 3, 4
- GABA-A receptor; alpha-1, 2, 5/beta-2, 3/gamma-2
- Galactocerebrosidase
- Galanin receptor type 3
- GATA4/NKX2-5
- Geminin
- Genome polyprotein
- Glucagon-like peptide 1 receptor
- Glucocorticoid receptor
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase
- Glutamate NMDA receptor
- Glutamate transporter homolog
- Glutaminase kidney isoform, mitochondrial
- Glutaminyl-peptide cyclotransferase
- Glutathione-independent formaldehyde dehydrogenase
- Glyceraldehyde-3-phosphate dehydrogenase
- Glycogen phosphorylase, muscle form
- Glycogen synthase kinase-3 alpha, beta
- Glycoprotein hormones alpha chain
- G-protein coupled bile acid receptor 1
- G-protein coupled receptor 35
- GroEL/GroES
- GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1
- Guanine nucleotide-binding protein G(i) subunit alpha-1, G(s) subunit alpha isoforms short
- H4
- H9c2
- Heat shock factor protein 1
- Heat shock protein HSP90
- Heme oxygenase 1
- Hemoglobin subunit beta
- Hepatocyte growth factor receptor
- Hexokinase HKDC1
- Hexose transporter 1
- High-affinity 3',5'-cyclic-AMP phosphodiesterase 7A
- High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
- High-affinity choline transporter 1
- Histamine H1, H3, H4 receptor
- Histidine kinase 3
- Histidine-tRNA ligase
- Histone acetyltransferase KAT2A, p300, RTT109
- Histone deacetylase 1, 2, 6
- Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
- Histone-lysine N-methyltransferase 2A, EHMT2, SETD7
- HSP40, 90
- HTH-type quorum-sensing regulator RhlR
- Human immunodeficiency virus type 1 integrase
- Human immunodeficiency virus type 1 protease
- Human immunodeficiency virus type 1 reverse transcriptase
- Hydroxycarboxylic acid receptor 2, 3
- Hypoxia-inducible factor 1-alpha
- Importin subunit beta-1/Snurportin-1
- Indoleamine 2,3-dioxygenase 1
- Induced myeloid leukemia cell differentiation protein Mcl-1
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Inosine-5'-monophosphate dehydrogenase
- Inositol hexakisphosphate kinase 2
- Inositol monophosphatase 1
- Insulin receptor
- Insulin-like growth factor 1 receptor
- Integrin alpha-L
- Interleukin-1 receptor antagonist protein
- Interleukin-8, 17A
- Isocitrate dehydrogenase [NADP] cytoplasmic
- Kallikrein-7
- Kappa-type opioid receptor
- Keap1-p62
- Kinesin-like protein KIF11
- Kir3.1/Kir3.2
- Krueppel-like factor 5, 10
- Kynurenine 3-monooxygenase
- Lactoylglutathione lyase
- Large neutral amino acids transporter small subunit 1
- L-asparaginase
- Legumain
- Lethal factor
- Lethal(3)malignant brain tumor-like protein 1
- Leucine aminopeptidase
- Leucine-rich repeat serine/threonine-protein kinase 2
- Leucyl-cystinyl aminopeptidase
- Leukotriene A-4 hydrolase
- LIM domain kinase 1
- Liver carboxylesterase 1
- L-lactate dehydrogenase A, B chain
- L-methionine gamma-lyase
- LSD1/CoREST complex
- Luciferin 4-monooxygenase
- Lysine-specific demethylase 1A, 4A, 4B, 4E, 5B
- Lysophosphatidic acid receptor 2
- Lysosomal acid glucosylceramidase
- Lysosomal alpha-glucosidase
- Lysyl oxidase homolog 2
- Macrophage migration inhibitory factor
- Macrophage-stimulating protein receptor
- Major prion protein
- Mannan-binding lectin serine protease 2
- MAP kinase-interacting serine/threonine-protein kinase 1
- Mast/stem cell growth factor receptor Kit
- Matrix metalloproteinase-9
- Matrix protein 2
- Melatonin receptor
- Menin/Histone-lysine N-methyltransferase MLL
- Metabotropic glutamate receptor 1, 4, 5, 7
- Methionine aminopeptidase
- Methionyl-tRNA synthetase, putative
- METTL3/METTL14
- Microphthalmia-associated transcription factor
- microRNA 21, 30a, 122
- Microtubule-associated protein tau
- Mitochondrial import inner membrane translocase subunit TIM10
- Mitogen-activated protein kinase
- Monocarboxylate transporter 1
- Monoglyceride lipase
- Mothers against decapentaplegic homolog 3
- Mucin-1
- Mucolipin-2, 3
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Multidrug resistance-associated protein 1
- Muscarinic acetylcholine receptor M1, M2, M4, M5
- Muscleblind-like protein 1
- Mushroom tyrosinase
- Mu-type opioid receptor
- Myc proto-oncogene protein
- Myeloperoxidase
- NACHT, LRR and PYD domains-containing protein 3
- N-acylethanolamine-hydrolyzing acid amidase
- NAD(P)H dehydrogenase [quinone] 1
- NAD-dependent protein deacetylase sirtuin-1, 2, 6
- NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
- NADPH oxidase 1
- N-arachidonyl glycine receptor
- Neprilysin
- Neuronal acetylcholine receptor
- Neuropeptide S receptor, Y receptor type 2, 4
- Neutrophil collagenase
- Neutrophil cytosol factor 1
- N-formyl peptide receptor 2
- N-glycosylase/DNA lyase
- Nicotinamide phosphoribosyltransferase
- Nicotinate phosphoribosyltransferase
- Nischarin
- Nitric oxide synthase
- Nociceptin receptor
- Non-receptor tyrosine-protein kinase TYK2
- Nonstructural protein 1, 3
- Nonstructural protein 3
- NPC intracellular cholesterol transporter 1
- Nuclear factor erythroid 2-related factor 2
- Nuclear factor NF-kappa-B complex
- Nuclear receptor coactivator 3
- Nuclear receptor ROR-gamma
- Nuclear receptor subfamily 0, 1, 4, 5 group B, I, A member 1, 2
- Nucleosome-remodeling factor subunit BPTF
- Nucleotide-binding oligomerization domain-containing protein 1, 2
- Olfactory receptor 5K1
- Opioid receptors; mu & delta
- Orexin receptor type 2
- Orexin/Hypocretin receptor type 1
- Organic anion transporter 3
- Organic cation/carnitine transporter 2
- Oxidized purine nucleoside triphosphate hydrolase
- Oxysterols receptor LXR-beta
- P2X purinoceptor 4, 7
- P2Y purinoceptor 1
- Paired box protein Pax-8
- Palmitoleoyl-protein carboxylesterase NOTUM
- Pancreatic triacylglycerol lipase
- Pantothenate kinase 3
- Paracentrotus lividus
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Patatin-like phospholipase domain-containing protein 2
- Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- Peroxisome proliferator-activated receptor alpha, delta, gamma
- Peroxisome proliferator-activated receptor gamma/Nuclear receptor coactivator 1, 2
- Phenylethanolamine N-methyltransferase
- Phosphatidylcholine transfer protein
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha, delta isoform
- Phosphatidylinositol 4-kinase beta
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
- Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
- Phosphodiesterase 1, 3, 4
- Phosphoglycerate kinase
- Phospholipase A2, D1
- Phosphoserine phosphatase SerB2
- Phosphotyrosine-protein phosphatase PTPB
- Photoreceptor-specific nuclear receptor
- Photosystem II protein D1
- Plasma kallikrein
- Plasmepsin II
- Plasminogen
- Platelet-activating factor receptor
- Platelet-derived growth factor receptor
- Plectin
- Poly [ADP-ribose] polymerase 1
- Poly [ADP-ribose] polymerase tankyrase-1, 2
- Poly(ADP-ribose) glycohydrolase
- Polyketide synthase Pks13
- Polyunsaturated fatty acid 5-lipoxygenase
- Polyunsaturated fatty acid lipoxygenase ALOX12, ALOX15
- Potassium channel subfamily K member 2
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
- Prelamin-A/C
- PRMT5/MEP50 complex
- Probable G-protein coupled receptor 139
- Probable L-lysine-epsilon aminotransferase
- Probable nicotinate-nucleotide adenylyltransferase
- Progesterone receptor
- Proline racemase
- Prolyl hydroxylase EGLN3
- Proprotein convertase subtilisin/kexin type 9
- Prostaglandin D2 receptor 2
- Prostaglandin E synthase
- Prostaglandin E2 receptor EP3 subtype
- Prostaglandin G/H synthase 1, 2
- Proteasome Macropain subunit MB1
- Proteasome subunit beta type-8
- Protein arginine N-methyltransferase 1, 5, 6
- Protein cereblon
- Protein disulfide-isomerase
- Protein kinase C zeta type
- Protein kinase Pfmrk
- Protein mono-ADP-ribosyltransferase PARP10, PARP11, PARP12, PARP14
- Protein RecA
- Protein S100-A4
- Protein smoothened
- Protein Tat
- Protein Wnt-3a
- Proteinase-activated receptor 1
- Protein-serine O-palmitoleoyltransferase porcupine
- Prothrombin
- Proto-oncogene tyrosine-protein kinase receptor Ret
- Proto-oncogene tyrosine-protein kinase Src
- Pteridine reductase, putative
- Putative uncharacterized protein
- Pyruvate dehydrogenase kinase
- Pyruvate kinase PKM
- quadruplex DNA
- Quinolone resistance protein NorA
- RAC-alpha serine/threonine-protein kinase
- Radical scavenging activity
- Rap guanine nucleotide exchange factor 3, 4
- Ras-related protein Rab-9A
- Receptor-interacting serine/threonine-protein kinase 1
- Receptor-type tyrosine-protein kinase FLT3
- RecQ-like DNA helicase BLM
- Regulator of G-protein signaling 4
- Relaxin receptor 1
- Replicase polyprotein 1ab
- Replicative DNA helicase DnaB
- Retinoic acid receptor beta, gamma
- Rho-associated protein kinase 1, 2
- Ribosomal protein S6 kinase beta-1
- rRNA adenine N-6-methyltransferase
- Runt-related transcription factor 1/Core-binding factor subunit beta
- S-adenosylmethionine synthase isoform type-2
- Secreted frizzled-related protein 1
- Sentrin-specific protease 1, 7, 8
- Sepiapterin reductase
- Serine hydroxymethyltransferase, mitochondrial
- Serine protease
- Serine/threonine-protein kinase 33, B-raf, Chk1, mTOR, Nek2, pim-1, pim-2, pim-3, PknG, PLK1, PLK4, SIK1
- Serine-protein kinase ATM
- Serotonin 2 receptors
- Serotonin 3 (5-HT3) receptor
- Serotonin N-acetyltransferase
- Shiga toxin
- Short transient receptor potential channel 4, 6
- Sialic acid-binding Ig-like lectin 9
- Sialidase-3
- Sigma non-opioid intracellular receptor 1
- Signal transducer and activator of transcription 3, 6
- Sodium- and chloride-dependent creatine transporter 1
- Sodium- and chloride-dependent GABA transporter 1
- Sodium-dependent dopamine transporter
- Sodium-dependent serotonin transporter
- Solute carrier family 2, 12, 22
- Solute carrier organic anion transporter family member 1B1, 1B3
- Son of sevenless homolog 1
- Sonic hedgehog protein
- Spermidine synthase
- Sphingosine 1-phosphate receptor 4
- Sphingosine kinase 1
- Squalene synthase
- STAM-binding protein
- Stearoyl-CoA desaturase
- Steroid 17-alpha-hydroxylase/17,20 lyase
- Steroidogenic factor 1
- Sterol 14-alpha demethylase
- Steryl-sulfatase
- Stimulator of interferon genes protein
- Streptavidin
- Streptokinase A
- Stromelysin-1
- Succinyl-diaminopimelate desuccinylase
- Sulfonylurea receptor 1, Kir6.2
- Sulfotransferase 1A1
- SUMO-activating enzyme
- Suppressor of tumorigenicity 14 protein
- Survival motor neuron protein
- Synaptic vesicular amine transporter
- T1R1/T1R3
- TAR DNA-binding protein 43
- Taste receptor type 2 member 14, 39
- TGF-beta receptor type-1
- Thiamine transporter ThiT
- Thioredoxin glutathione reductase
- Thioredoxin reductase
- Thiosulfate sulfurtransferase
- Thymidine phosphorylase
- Thymidylate synthase
- Thyroid hormone receptor beta
- Thyrotropin receptor
- Thyrotropin-releasing hormone receptor
- Toll-like receptor 2, 4, 7
- Trace amine-associated receptor 1
- Trans-cinnamate 4-monooxygenase
- Transcription factor SKN7
- Transcription intermediary factor 1-alpha
- Transcriptional activator protein LasR, LuxR
- Transcriptional regulator ERG, MvfR
- Transient receptor potential cation channel subfamily A member 1
- Transient receptor potential cation channel subfamily M member 7, 8
- Transient receptor potential cation channel subfamily V member 1
- Translocator protein
- Trans-sialidase
- Transthyretin
- Triosephosphate isomerase, glycosomal
- Troponin, cardiac muscle
- Trypsin
- Tryptophan 2,3-dioxygenase
- Tryptophan-tRNA ligase
- Tumor necrosis factor
- Tumour suppressor p53/oncoprotein Mdm2
- Type-1 angiotensin II receptor
- Tyrosinase
- Tyrosine-protein kinase ABL1, Fyn, Lck, SYK
- Tyrosine-protein phosphatase non-receptor type 1, 7, 11, 22
- Tyrosyl-DNA phosphodiesterase 1
- Ubiquitin carboxyl-terminal hydrolase 1, 2, 7, 8, 10, L3
- Ubiquitin-conjugating enzyme E2 N
- UDP-N-acetylglucosamine 1-carboxyvinyltransferase
- UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit
- Urea transporter 1, 2
- Urease
- Uridine phosphorylase 1
- Vascular cell adhesion protein 1
- Vascular endothelial growth factor receptor 2
- Vasoactive intestinal polypeptide receptor 1
- Very long chain fatty acid elongase 6
- Vitamin D3 receptor
- Voltage-dependent calcium channel subunit alpha-2/delta-1
- Voltage-dependent N-type calcium channel subunit alpha-1B
- Voltage-dependent T-type calcium channel subunit alpha-1G, alpha-1H
- Voltage-gated inwardly rectifying potassium channel KCNH2
- Voltage-gated L-type calcium channel
- WD repeat-containing protein 5
- Xanthine dehydrogenase/oxidase
- X-box-binding protein 1
- Zinc finger protein Aiolos, mex-5