Early Drug Discovery Services

Life Chemicals offers the entire scope of its products and services to open up widest horizons of our customers’ drug discovery endeavor, starting with most daring ideas and obtaining molecules to test and implement these ideas.

Entering the very first stage of your search for an appropriate product candidate by scrutinizing our stock HTS library, you can take best advantage of our tangible structures, chemoinformatics, MedChem design and all relevant services, presented below, to get compounds completely ready for screening:

Stock Collection
  • Over 460,000 HTS compounds based on 2,900 innovative scaffolds
  • 50,000 Diversity Library
  • Fragment Libraries
  • Targeted and Focused Libraries
  • 11,000 building blocks
Chemoinformatic Services
  • Substructure search
  • Similarity/dissimilarity search
  • Custom parameters filtering
  • Virtual docking screening
  • Protein modeling
  • Expertise of 3 PhDs
Library Formatting
  • Dry powders or DMSO solutions
  • Automated liquid handling lab in the USA
  • Standard 4mL Kimble/Kontes amber glass vials with teflon-lined screw caps
  • Microtubes in microracks, single/loose
  • mg or μmol amounts
  • Barcoding and labeling as per customer’s requirements
MedChem Design
  • Over 10 years’ experience in BigPharma MedChem projects
  • In-house, customized or combined library design
  • Most up-to-date MedChem concepts
  • Lead-oriented scaffold-based Libraries
  • Conformational restriction
  • Bioisosteric replacements
  • Scaffold hopping
  • Peptidomimetics
  • Scaffold-based libraries
  • Hit follow-up and SAR
Quality Control
  • 10 analytical chemists (1 PhD, 7 MSc, 2 BSc)
  • Varian 400MHz and 300MHz NMR (¹H, ¹³C, other nuclei, 2D NMR)
  • Agilent 1200/1100 HPLC-MS
  • Agilent 7890 GS-MS
  • Karl Fisher titration, elemental analysis and other techniques
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