Novel Generative AI Designed Target Selective Compounds

In partnership with Variational AI, Life Chemicals designs and synthesizes novel, selective small molecule compounds  targeting key kinases and GPCRs of interest in modern drug discovery.

Variational AI is the developer of the Enki^TM generative artificial intelligence (AI) platform for drug discovery. The Enki™ Lead Generator module generates de novo compounds for your discovery program needs and is trusted by leading biopharmaceutical companies for early-stage drug discovery. For more information on Variational AI, see:  https://variational.ai/.

Life Chemicals provides for analysis of its proprietary stock and tangible HTS Compound Collections for the library design, coupled with Custom Synthesis Services on demand to streamline the project workflow.

Lists of currently available Kinase and GPCR Targets are provided below. The range of drug targets is continuously expanding. Please send us an inquiry about your target of interest if you cannot find it in the lists below

The compound selection can be customized based on your requirements, cherry picking is available.

Please, contact us at orders@lifechemicals.com for any additional information and price quotations.

Enki™ platform

Enki™ Lead Generator is based on a fully-trained generative AI foundation model that rapidly generates novel and diverse leads. Enki^TM Lead Generator is based on a novel and proprietary machine learning model designed from the ground up for modeling the pharmacological properties of small molecules, combined with a carefully filtered and curated dataset of over 2M experimental dose-response potency data points across hundreds of kinases and GPCRs, as well as structure-based evaluations of 400M ligand-target pairs. Enki™ Lead Generator predicts experimental potency with accuracy comparable to absolute binding free energy methods. It provides novel, lead-like, and developable compounds for further synthesis and evaluation. Enki™ Lead Optimizer is available separately for lead optimization campaigns.

Enki™ Lead Generator Compound selection workflow

A simple three-step process is involved in the preparation of the custom compound selection for a target of interest:

1. Submit your specific target product profiles (TPPs)
2. We will perform the analysis. Novel, diverse, selective, and synthesizable lead-like structures will be sent to you electronically for evaluation in days to weeks depending on the TPP.
3. Based on your compound selection, Life Chemicals can provide quick and efficient synthesis to ship them to you for pharmacological evaluation.

Sample output of 1 of 100 structures based on two on-targets:

The list of currently offered 125 Kinase Targets

The list of currently offered 38 GPCR Targets