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Featured Products
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Covalent Kinase Screening Library
new
A dedicated set of over 4,200 potential kinase covalent inhibitors represented by 10 diverse electrophilic warheads was designed by our cheminformatics team. The warheads were selected by molecular docking, using the Life Chemicals proprietary collection of kinase-focused Screening Sets. These potential covalent modifiers of protein kinase are aimed at facilitating drug discovery projects devoted to targeted cancer therapy, inflammatory and autoimmune diseases.
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Apoptosis Signaling Pathway Screening Library
new
We developed this screening set of over 26,800 drug-like compounds potentially targeting various proteins of the apoptotic signaling pathway to provide a new effective tool for apoptosis-related drug discovery. Close analogs of molecules with high experimental activity against apoptotic pathway targets were selected through a 2D fingerprint similarity search against our proprietary HTS Compound Collection.
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Helicase Screening Libraries
updated
During our analysis, more than 7,000 potential helicase inhibitors were selected with ligand- and receptor-based cheminformatics approaches. These drug-like screening compounds are considered to open up excellent prospects for drug discovery dealing with infectious diseases and cancer. Youu can take advantage of cherry-picking or order assay-ready Pre-plated Helicase Screening Set for your convenience.
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Zinc Nuclear Finger (ZNF) Protein Screening Library
new
ZNF proteins are known to be responsible for different biological processes, in particular, controlling transcription, post-transcriptional regulation, and facilitating protein-protein interactions. Although understanding these promising proteins is advancing, they are still relatively underexplored targets for modern drug discovery. To cover this gap, our team has created a unique screening set of over 2,000 drug-like compounds that can potentially target zinc nuclear finger proteins selectively.
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Pre-plated Screening Compound Sets
updated
To enhance the effectiveness of your drug discovery research, Life Chemicals meticulously creates and continually updates its expanding collection of pre-plated screening sets.They are based on our best-selling screening compound libraries. The assay-ready Screening Pools have consistently proven to be highly promising and efficient resources for performing high throughput screening (HTS), high content screening (HCS), and fragment-based drug discovery (FBDD) campaigns.
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Fsp³-enriched Screening Compound Library
updated
We selected 62,000 sp3-rich screening compounds from the Life Chemicals proprietary HTS Compound Collection that possess an increased Fsp3 fraction ≥ 0.47 (mean value of 0.60). They offer a high degree of chemical and structural diversity. Many of these novel drug-like molecules feature spiro, bridged, and fused rings, as well as stereogenic centers, which collectively cover a more advantageous chemical space. Additionally, Fsp3-enriched Fragment Library comprises around 21,500 non-flat 3D fragments for FBDD.
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RNA-associated Protein Screening Library
new
RNA-binding proteins (RBPs) are pivotal in cellular processes, encompassing gene expression and RNA metabolism. Their dysregulation is associated with tumorigenesis, making them valuable targets in post-transcriptional gene regulation and anticancer drug discovery. To facilitate hit finding in these areas, we have prepared a collection of 6,500 drug-like small-molecule compounds predicted to possess RNA-associated protein binding activity.
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DNA and RNA Polymerase Screening Libraries
new
Considering that DNA Polymerases and Reverse Transcriptases are key molecular targets in antiviral and antitumor chemotherapy, we have employed ligand- and receptor-based virtual screening methods to identify small-molecule analogs of polymerase inhibitors against drug targets associated with RNA and DNA polymerase targets.
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Anti-HIV Screening Compound Libraries
new
Life Chemicals actively supports antiretroviral drug discovery research by providing exclusive Anti-HIV Focused and Targeted Sets. They include more than 20,000 drug-like and structurally diverse screening compounds, all of which have the potential to act as inhibitors for specific HIV-related molecular targets, such as HIV1 protease, reverse transcriptase, integrase, and others.
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