Leading supplier of HTS compounds, building blocks

Featured Products

DNA-encoded (DEL) Reagents and Building Blocks

new

Life Chemicals offers over 70,000 mono-functional or protected bi-functional and tri-functional building blocks, scaffolds, and fragment compounds suitable for DNA-encoded chemical libraries (DEL) preparation. A custom selection of compounds by any parameter is available on request.

CNS Screening Library

updated

9,900 small-molecule potentially CNS-penetrant compounds were selected using the optimal threshold values for the main physicochemical parameters and the MPO desirability score. The compound set is aimed to facilitate the CNS-targeted drug design projects and HTS efforts in the search for novel neurotherapeutics. PAINS and toxicophore-containing compounds were removed by in-house medchem filters.

Pre-plated Focused Libraries

new

Our Pre-plated Focused Libraries are aimed to provide convenient starting kits for hit identification in the HTS and HCS drug discovery projects. The compound sets comprise novel drug-like screening compounds synthesized in-house. Several formatting options are available.

Pre-plated Diversity Sets

updated

Exclusive non-overlapping Pre-plated Diversity Sets are composed of 5,000, 10,000, 15,000, and 20,000 screening compounds (in total, 50,000 novel structurally-diverse molecules) with optimal physico-chemical properties, selected by dissimilarity search with the average Tanimoto threshold of 80%. They are ideal starting kit for phenotypic and target-based HTS.

Cysteine-related Libraries for Anti-coronavirus Research

new

Life Chemicals efforts to contribute to fighting the COVID-19 resulted in a number of compound libraries, including those specifically focused on cysteine: Cysteine Protease Library (3,700 screening compounds), Cysteine Focused Covalent Inhibitor Library (2,200 potential covalent modifiers), Cysteine Focused Covalent Inhibitor Fragments (1,200 fragments), 2019-nCoV Main Protease Targeted Library (2,300 potential inhibitors).

Anti-HIV Screening Libraries

new

Life Chemicals contributes to antiretroviral research with a set of Anti-HIV Screening Libraries, including HIV Focused Library (24,00 drug-like screening compounds), HIV Reverse Transcriptase Library (2,100 potential inhibitors) and HIV Protease Library (760 structurally diverse molecules), designed by 2D fingerprint similarity search. Customizable compound selection and cherry-picking are easily available.

Nuclear Receptor Screening Libraries

new

Nuclear receptors are promising drug targets for treatment of inflammatory diseases, cancer, and diabetes. Our Nuclear Receptor Screening Libraries comprise over 5,000 screening compounds selected by the protein-ligand docking method, together with 6,000 drug-like molecules picked by 2D fingerprint similarity search against nuclear receptor bioactivity records in ChEMBL.

Phenotypic Screening Libraries

new

To facilitate phenotypic drug discovery screening, Life Chemicals has designed two dedicated Phenotypic Screening Libraries: ChemDiversity (7,500 drug-like screening compounds) and BioDiversity (11,000 bioactive molecules and their analogs, together with natural product-related compounds). The Libraries are characterized by high chemical and biological diversity and optimal physicochemical properties.