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On February 24, 2022, the life of the Ukrainian people changed forever! Russia invaded the territory of Ukraine and the war started in the center of Europe! Now the bell tolls for everyone! Russia’s unprecedented and atrocious invasion is destroying not only the country’s economy but bringing inhuman suffering to the civilians.

Stop business with Russia! Do not be involved with the aggressor!

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Featured Products
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Pre-plated Focused Libraries: Latest additions
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Our collection of screening libraries in pre-plated format is growing rapidly! Take advantage of the most favorable terms to boost your hit-finding HTS drug discovery projects! Recently we’ve added a kinase diversity set, 3D-shaped molecules, antibacterial compounds as well as PPI and PI3K/Akt/mTOR inhibitors in pre-plated assay-ready format. All compounds are synthesized in-house and several formatting options are available.
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Pre-plated Diversity Sets
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Our exclusive non-overlapping Pre-plated Diversity Sets containing 50,000 novel structurally diverse molecules were selected by dissimilarity search to provide a higher variety and broader chemical space coverage. They are an ideal starting kit for phenotypic and target-based HTS. Smaller subsets of 5,000, 10,000, 15,000, and 20,000 screening compounds are also available to meet your research needs.
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Diversity Fragment Subsets
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We have applied our broad expertise in medicinal chemistry to provide you with compact screening sets, a perfect starting point for FBDD campaigns. They contain 960 or 1600 of our best fragment-like molecules with maximal structure diversity to cover the broadest chemical space. Specific subsets are available to provide the most suitable solutions to different research approaches: fluorinated and brominated compounds, Fsp³-enriched molecules, and potential covalent binders.
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Advanced Building Block Collection
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Our proprietary collection of building blocks is predominantly based on rare chemotypes with favorable physicochemical parameters. The Life Chemicals R & D team performs the design and in-house synthesis of novel molecules, chemical intermediates, and fine reagents bearing various reactive functional groups to provide the most promising reagents for medicinal chemistry and drug design.
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Natural Product-like Compound Libraries
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We have selected over 7,700 synthetic compounds similar to natural ones applying cheminformatics approaches (chemical descriptor calculation and natural-likeness scoring) and similarity to natural compound scaffolds. This is a perfect tool for high throughput screening (HTS) and high content screening (HCS) programs in modern drug discovery.
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Covalent Screening Library
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A proprietary collection of 34,700 potential covalent modifiers was prepared to best suit various covalent screening projects in drug discovery. These small-molecule screening compounds contain covalent warheads known to form covalent bonds with amino acid residues in binding sites of target proteins. Additional focused sets of covalent binders targeting specific amino acid residues can be provided on request.
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3D Compound Libraries for HTS
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The 3D shape of a free ligand is a crucial feature for its molecular recognition by the desired biomolecule and affinity to the binding site. Explore our new proprietary collection of over 30,000 non-planar sp3-rich screening compounds with diverse and well-developed 3D shapes as remarkably attractive molecules for HTS in modern drug discovery.
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Serine Protease Screening Libraries
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Our freshly picked Serine Protease Targeted Library contains 6,400 structurally-diverse screening compounds picked out by receptor-based virtual molecular screening with predicted inhibitory activity against main serine proteases: trypsin, chymotrypsin, a subtilisin-like serine protease, thrombin, factor Xa (FXA), and elastase. Serine proteases are involved in digestion coordination, inflammation, blood clotting, and immune system performance and represent a promising drug target family.
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