Featured Products
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DNA-encoded (DEL) Reagents and Building Blocks
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Life Chemicals offers over 70,000 mono-functional or protected bi-functional and tri-functional building blocks, scaffolds, and fragment compounds suitable for DNA-encoded chemical libraries (DEL) preparation. A custom selection of compounds by any parameter is available on request.
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CNS Screening Library
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9,900 small-molecule potentially CNS-penetrant compounds were selected using the optimal threshold values for the main physicochemical parameters and the MPO desirability score. The compound set is aimed to facilitate the CNS-targeted drug design projects and HTS efforts in the search for novel neurotherapeutics. PAINS and toxicophore-containing compounds were removed by in-house medchem filters.
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Pre-plated Focused Libraries
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Our Pre-plated Focused Libraries are aimed to provide convenient starting kits for hit identification in the HTS and HCS drug discovery projects. The compound sets comprise novel drug-like screening compounds synthesized in-house. Several formatting options are available.
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Pre-plated Diversity Sets
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Exclusive non-overlapping Pre-plated Diversity Sets are composed of 5,000, 10,000, 15,000, and 20,000 screening compounds (in total, 50,000 novel structurally-diverse molecules) with optimal physico-chemical properties, selected by dissimilarity search with the average Tanimoto threshold of 80%. They are ideal starting kit for phenotypic and target-based HTS.
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Cysteine-related Libraries for Anti-coronavirus Research
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Life Chemicals efforts to contribute to fighting the COVID-19 resulted in a number of compound libraries, including those specifically focused on cysteine: Cysteine Protease Library (3,700 screening compounds), Cysteine Focused Covalent Inhibitor Library (2,200 potential covalent modifiers), Cysteine Focused Covalent Inhibitor Fragments (1,200 fragments), 2019-nCoV Main Protease Targeted Library (2,300 potential inhibitors).
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Anti-HIV Screening Libraries
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Life Chemicals contributes to antiretroviral research with a set of Anti-HIV Screening Libraries, including HIV Focused Library (24,00 drug-like screening compounds), HIV Reverse Transcriptase Library (2,100 potential inhibitors) and HIV Protease Library (760 structurally diverse molecules), designed by 2D fingerprint similarity search. Customizable compound selection and cherry-picking are easily available.
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Nuclear Receptor Screening Libraries
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Nuclear receptors are promising drug targets for treatment of inflammatory diseases, cancer, and diabetes. Our Nuclear Receptor Screening Libraries comprise over 5,000 screening compounds selected by the protein-ligand docking method, together with 6,000 drug-like molecules picked by 2D fingerprint similarity search against nuclear receptor bioactivity records in ChEMBL.
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Phenotypic Screening Libraries
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To facilitate phenotypic drug discovery screening, Life Chemicals has designed two dedicated Phenotypic Screening Libraries: ChemDiversity (7,500 drug-like screening compounds) and BioDiversity (11,000 bioactive molecules and their analogs, together with natural product-related compounds). The Libraries are characterized by high chemical and biological diversity and optimal physicochemical properties.