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Featured Products
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RNA Focused and Targeted Libraries
updated
Belonging to the three major biological macromolecules essential for all known forms of life, RNA is involved in the progression of various diseases, including infectious (HIV, hepatitis C), metabolic (diabetes, cancer), and triplet repeat (myotonic dystrophy, Huntington’s disease) disorders. Life Chemicals has always devoted itself to tackling most essential R & D problems and in doing so, we offer 3,300 drug-like compounds with predicted RNA-binding activity as an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery.
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Exclusive Pre-plated Diversity Sets
updated
Our Pre-plated Diversity Sets ideally provide a unique starting kit for phenotypic and target-based HTS. We offer 100,000 novel structurally diverse molecules, selected by dissimilarity search to create a higher variety and broader chemical space coverage. Smaller non-overlapping subsets of 5,000, 10,000, 15,000, and 20,000 screening compounds are also available to find an optimal solution for your research needs.
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Fsp³-enriched Screening Compound Library
updated
62,000 sp3-rich non-flat screening compounds from the Life Chemicals proprietary HTS Compound Collection. These novel drug-like molecules possess an increased Fsp3 fraction ≥ 0.47 (mean value 0.57), as well as high chemical and structural diversity. Many structures contain spiro, bridged and fused rings and stereogenic centers to cover more advantageous chemical space.
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Ion Channel Screening Libraries
updated
Although ion channels are the key players of communication in the nervous system, they are underexploited molecular targets in drug development. Here and now, the wonderful world of ion channels can expertly be targeted with our screening compounds.
To boost the discovery of novel ion channel ligands, we offer structurally-diverse screening compounds that are potential small-molecule ion channel modulators, selected by both ligand-based and receptor-based approaches.
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Carbonic Anhydrase Targeted Library
new
Alpha-carbonic anhydrases, zinc-containing metalloenzymes, are known to catalyze efficiently the reversible hydration of carbon dioxide to bicarbonate. At present, several carbonic anhydrase inhibitors are used in clinics as antiglaucoma drugs, antitumor agents, anticonvulsants, and antimicrobials, antifungals. With this in mind, we have applied receptor-based virtual screening to carefully prepare a new and original library of 3,200 drug-like screening compounds targeting five different isoforms of human carbonic anhydrase: I, II, XII, XIII, and XIV.
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Fragment Diversity Subsets for FBDD
updated
Our profound expertise in medicinal chemistry allowed us to prepare compact screening sets as a perfect starting point for FBDD campaigns. They contain 960 or 1,600 of our best fragment-like molecules with maximal structure dissimilarity to cover the broadest chemical space. Providing the most suitable solutions to different research tasks, available are specific subsets which include fluorinated and brominated compounds, Fsp³-enriched molecules, and potential covalent binders.
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Fragment Library with Experimental Solubility
updated
An early assessment of solubility provides valuable information for better interpretation of screening results and the design of new molecules in drug discovery projects. Explore our 22,500 readily available fragments with confirmed solubility in PBS and DMSO!
The Library is regularly updated with newly synthesized compounds, rigorously filtered by physicochemical and structural parameters.
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CNS Screening Library
updated
9,900 small-molecule potentially CNS-penetrant compounds were selected using the optimal threshold values for the main physicochemical parameters and the MPO desirability score. The compound set is aimed to facilitate the CNS-targeted drug design projects and HTS efforts in the search for novel neurotherapeutics. PAINS and toxicophore-containing compounds were removed by in-house medchem filters.
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