Featured Products
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Protein-protein interaction (PPI) Screening Libraries
updated
Keeping pace with a growing interest in the inhibition of Protein-protein interactions (PPIs) with small molecules, Life Chemicals offers a proprietary collection of potential PPI modulators. PPI-focused screening compounds were selected by both ligand-based and receptor-based approaches.
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Antibacterial Library
updated
Antibacterial Screening Library by Life Chemicals contains drug-like screening compounds with potential antibacterial activity against different gram-positive and gram-negative bacteria species and bacteria-related protein targets. It is a product to enjoy in your HTS and HCS for antibacterial drug discovery projects.
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Covalent Inhibitor Library
updated
The Library comprises over 10,000 covalent modifiers containing specific functional groups (“warheads”), that are known to form covalent bonds with amino acid residues (Lys, Cys, Ser, Asp, Glu, and Tyr) in binding sites of target proteins. The extended Rule of Five criteria were applied for the compound selection. Additional separate focused sets of covalent binders targeting each of the indicated amino acid residues can be provided on request.
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RNA Focused Library
updated
RNA is involved in progression of various diseases, including infectious, metabolic and triplet repeat disorders. Life Chemicals has recently updated its proprietary RNA Screening Library. Over 4,400 novel drug-like screening compounds with predicted RNA-binding activity were selected with two ligand-based approaches. It is an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.
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Nuclear Receptor Screening Libraries
new
Nuclear receptors are promising drug targets for treatment of inflammatory diseases, cancer, and diabetes. Our Nuclear Receptor Screening Libraries comprise over 5,000 screening compounds selected by the protein-ligand docking method, together with 6,000 drug-like molecules picked by 2D fingerprint similarity search against nuclear receptor bioactivity records in ChEMBL.
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DNA-encoded (DEL) Reagents and Building Blocks
new
Life Chemicals offers over 70,000 mono-functional or protected bi-functional and tri-functional building blocks, scaffolds, and fragment compounds suitable for DNA-encoded chemical libraries (DEL) preparation. A custom selection of compounds by any parameter is available on request.
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Pre-plated Focused Libraries
new
Our Pre-plated Focused Libraries are aimed to provide convenient starting kits for hit identification in the HTS and HCS drug discovery projects. The compound sets comprise novel drug-like screening compounds synthesized in-house. Several formatting options are available.
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Degrader Building Blocks for Targeted Protein Degradation
new
Life Chemicals presents its new PROTAC Building Blocks Library, composed of over 1,500 compounds that are highly similar to known E3 ligases inhibitors as well as of linker-like molecules (PEGs, Alkyl-Chain, and Alkyl/ether). The Library has been designed based on the structure and activity data for known PROTACS and E3 ligase binders (2D fingerprints similarity search, Tanimoto ≥ 0.80) and general structural properties of known PROTAC crosslinkers.
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