Covalent Inhibitor Library
The Library comprises over 10,000 covalent modifiers containing specific functional groups (“warheads”),
that are known to form covalent bonds with amino acid residues (Lys, Cys, Ser, Asp, Glu, and Tyr) in
binding sites of target proteins. The extended Rule of Five criteria were applied for the compound
selection. Additional separate focused sets of covalent binders targeting each of the indicated amino
acid residues can be provided on request.