Featured Products
Read More
2019-nCoV Papain-Like Protease Targeted Library
new
This new screening compound set belongs to our dedicated Coronavirus Screening Libraries, intended for development of innovative and specific antiviral therapeutics towards COVID-19. 1,700 potential inhibitors of the SARS CoV-2 papain-like protease (PLpro) were selected by docking-based virtual screening from the Life Chemicals HTS Compound Collection.
Read More
Pre-plated Focused Libraries
new
Our Pre-plated Focused Libraries are aimed to provide convenient starting kits for hit identification in the HTS and HCS drug discovery projects. The compound sets comprise novel drug-like screening compounds synthesized in-house. Several formatting options are available.
Read More
STING Targeted Library
new
The new STING Targeted Library comprises potential agonists of the cellular double-stranded DNA sensor STING. It was created by docking-based virtual screening, resulting in 1,600 drug-like compounds (Ro5-compliant, reactive and toxic groups removed). The docking score value is available for each compound in the compound structure file provided on requests.
Read More
Antiviral Screening Libraries
updated
Antiviral Libraries were designed with 2D similarity or a combination of ligand-based structure-based approaches and aim high throughput screening (HTS) and high content screening (HCS) projects. Over 13,700 drug-like screening compounds with potential antiviral activity against various virus species and antiviral molecular targets were selected.
Read More
Pre-plated Diversity Sets
updated
Exclusive non-overlapping Pre-plated Diversity Sets are composed of 5,000, 10,000, 15,000, and 20,000 screening compounds (in total, 50,000 novel structurally-diverse molecules) with optimal physico-chemical properties, selected by dissimilarity search with the average Tanimoto threshold of 80%. They are ideal starting kit for phenotypic and target-based HTS.
Read More
Cysteine-related Libraries for Anti-coronavirus Research
new
Life Chemicals efforts to contribute to fighting the COVID-19 resulted in a number of compound libraries, including those specifically focused on cysteine: Cysteine Protease Library (3,700 screening compounds), Cysteine Focused Covalent Inhibitor Library (2,200 potential covalent modifiers), Cysteine Focused Covalent Inhibitor Fragments (1,200 fragments), 2019-nCoV Main Protease Targeted Library (2,300 potential inhibitors).
Read More
Phenotypic Screening Libraries
new
To facilitate phenotypic drug discovery screening, Life Chemicals has designed two dedicated Phenotypic Screening Libraries: ChemDiversity (7,500 drug-like screening compounds) and BioDiversity (11,000 bioactive molecules and their analogs, together with natural product-related compounds). The Libraries are characterized by high chemical and biological diversity and optimal physicochemical properties.
Read More
RNA Focused Library
updated
Life Chemicals has developed its RNA Screening Library of over 3,300 drug-like compounds with predicted RNA-binding activity as an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research. It has been designed with two ligand-based approaches: 2D Similarity Search and Bayesian Modeling.