We offer a recently-updated collection of over 49,000 fragments, readily available for fragment-based lead discovery (FBLD) projects. Specific subsets are available to provide the most suitable solutions for different research approaches (such as NMR, high-throughput X-ray crystallography, high concentration bioassay, SPR). Explore our Fsp3-enriched and 3D fragments, fluorinated, brominated and covalent fragments, high solubility subset, and many more.

Ligases are enzymes that catalyze the reaction of joining two large molecules by establishing a new chemical bond. They play an important role in tumorigenesis and cancer development. Life Chemicals has recently designed a new screening set containing drug-like small-molecule analogs of reported ligase inhibitors against over 20 ligase enzyme targets.

Glutamate is the major excitatory neurotransmitter in the CNS that modulates synaptic responses by activating ionotropic glutamate (iGlu) receptors and GPCRs-termed metabotropic glutamate (mGlu) receptors. We present a proprietary collection of 4,600 analogs of known glutamate receptor modulators to facilitate glutamate-based drug discovery projects for neurological disorders.

Keeping pace with a growing interest in the inhibition of Protein-protein interactions (PPIs) with small molecules, Life Chemicals offers a proprietary collection of potential PPI modulators. PPI-focused screening compounds were selected by both ligand-based and receptor-based approaches.

Antibacterial Screening Library by Life Chemicals contains drug-like screening compounds with potential antibacterial activity against different gram-positive and gram-negative bacteria species and bacteria-related protein targets. It is a product to enjoy in your HTS and HCS for antibacterial drug discovery projects.

Hepatitis C virus (HCV) is a leading cause of liver‐related morbidity and mortality worldwide. To facilitate the search for new antiviral agents against hepatitis C, we have prepared the Anti-HCV Library using molecular docking. Three proteins of the viral capsid were used as targets. In addition, a small subset against Hepatitis A and B viruses was prepared with a 2D similarity search.

The Library comprises over 10,000 covalent modifiers containing specific functional groups (“warheads”), that are known to form covalent bonds with amino acid residues (Lys, Cys, Ser, Asp, Glu, and Tyr) in binding sites of target proteins. The extended Rule of Five criteria were applied for the compound selection. Additional separate focused sets of covalent binders targeting each of the indicated amino acid residues can be provided on request.

RNA is involved in progression of various diseases, including infectious, metabolic and triplet repeat disorders. Life Chemicals has recently updated its proprietary RNA Screening Library. Over 4,400 novel drug-like screening compounds with predicted RNA-binding activity were selected with two ligand-based approaches. It is an excellent starting point for post-transcriptional gene regulation, antibacterial, and antiviral drug discovery research.