Featured Products
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Pre-plated Diversity Sets
new
Our exclusive non-overlapping Pre-plated Diversity Sets containing 50,000 novel structurally diverse molecules were selected by dissimilarity search to provide a higher variety and broader chemical space coverage. They are an ideal starting kit for phenotypic and target-based HTS. Smaller subsets of 5,000, 10,000, 15,000, and 20,000 screening compounds are also available to meet your research needs.
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Immuno-oncology Screening Libraries
new
To address growing needs for novel and potent therapeutics that block inhibitory receptors or activate immune-stimulatory checkpoint receptors, this special screening compound library focused on already established and only emerging immuno-oncology targets has been designed. Over 3,700 structurally diverse small molecules were selected with docking-based virtual screening for modern anticancer drug discovery.
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Natural Product-like Compound Libraries
updated
We have selected over 7,700 synthetic compounds similar to natural ones applying cheminformatics approaches (chemical descriptor calculation and natural-likeness scoring) and similarity to natural compound scaffolds. This is a perfect tool for high throughput screening (HTS) and high content screening (HCS) programs in modern drug discovery.
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Covalent Screening Library
updated
A proprietary collection of 34,700 potential covalent modifiers was prepared to best suit various covalent screening projects in drug discovery. These small-molecule screening compounds contain covalent warheads known to form covalent bonds with amino acid residues in binding sites of target proteins. Additional focused sets of covalent binders targeting specific amino acid residues can be provided on request.
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3D Compound Libraries for HTS
new
The 3D shape of a free ligand is a crucial feature for its molecular recognition by the desired biomolecule and affinity to the binding site. Explore our new proprietary collection of over 30,000 non-planar sp3-rich screening compounds with diverse and well-developed 3D shapes as remarkably attractive molecules for HTS in modern drug discovery.
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Transcription-related Screening Library
new
Many diseases, such as neurodegenerative disorders, diabetes, and cancer, are associated with the deregulation of transcriptional networks. To support the transcription-related drug discovery, we have designed a dedicated set of over 9,200 small-molecule screening compounds that are potential modulators of transcription-associated protein targets.
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SH2 Domain Focused Library
new
Explore our new selection of 2,200 drug-like screening compounds with predicted affinity to SH2 domains prepared by a receptor-based approach. Src homology 2 (SH2) domains are modular units of 100 amino acids that bind to recognized by them tyrosyl-phosphorylated peptide sequences on target receptor tyrosine kinases and other signaling proteins, mediating intracellular protein-protein interactions and overactivated in various diseases (including cancer, diabetes, immune deficiency).
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Kinase Screening Library
new
Our Kinase Screening Library aims to provide initial hits for drug discovery projects related to kinases and other ATP-binding proteins. It was designed based on Markush structures and pharmacophore models of known kinase inhibitors. Exploring this Library of 3,000 drug-like screening compounds, you can find potential inhibitors targeting key protein kinases in cancer and inflammation, which were selected by 2D similarity search.
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