Covalent Inhibitor Libraries for Various Drug Discovery Projects

In response to the vividly growing interest in covalent inhibitors as drugs, we keep improving and enlarging our proprietary collection of Covalent Inhibitor Libraries:

• The main Covalent Screening Library currently offers over 54,000 carefully selected potential covalent binders, having been recently enlarged with over 20,000 newly-synthesized molecules.
• The Cysteine Focused Covalent Inhibitor Library contains 13,900 potential covalent modifiers with specific structure moieties that can react with cysteine residues of a drug target reversibly or irreversibly.
• Built on the basis of the Cys-focused Diversity Screening Set, there is a user-oriented Pre-plated Cysteine Covalent Set of 3,520 assay-ready compounds.
• Our new Histidine Focused Covalent Library includes 5,600 small-molecule screening compounds that are potential histidine-specific covalent inhibitors.
• Recently remastered, the Serine Focused Covalent Inhibitor Library presents 3,800 structurally diverse compounds selected out of 25,000 potential serine covalent inhibitors from our proprietary HTS Compound Collection.
• The latest addition to the collection introduced here is the Covalent Kinase Screening Library of 4,200 potential kinase covalent inhibitors containing ten diverse electrophilic warheads, chosen by molecular docking based on our proprietary Kinase-focused Screening Sets.
• The Covalent Fragment Library, carefully designed for covalent fragment screening, is made up of 6,500 fragments, also available pre-plated in an assay-ready format as four screening subsets.

Please, contact us at orders@lifechemicals.com for any additional information and price quotations.

Please feel free to send your inquiries on a specific protein drug target needed, and our cheminformatics team will be happy to assist you in the structure optimization of potential irreversible binders, as well as in performing virtual covalent docking.
Recommended for your convenient reference is our page on How to Find Reactive Screening Compounds in the eShop.