Proteases (proteinases or peptidases) are a class of enzymes that catalyze proteolysis, breakdown of proteins into smaller polypeptides or single amino acids by cleaving peptide bonds via hydrolysis. Proteases are involved in many biological functions, such as cell signaling, protein catabolism (the breakdown of old proteins), and digestion of ingested proteins.
Proteinases are considered promising drug targets for diseases ranging from cardiovascular disorders to cancer and, what is more, combating many parasites and viruses. Nonetheless, drug development for new protease targets has recently turned out to be rather challenging due to various factors, in particular, the difficulty of achieving selectivity when targeting protease active sites .
Life Chemicals offers a proprietary collection of drug-like screening compounds with predicted protease inhibitory activity to facilitate protease-based drug discovery efforts. Potential protease-targeted modulators were selected, using both ligand-based (computational chemistry, 2D fingerprint similarity search) and receptor-based (high-throughput virtual screening, flexible and covalent docking) approaches.
Compound cherry-picking within each screening library is available. Custom compound selection based on specific parameters can be performed, with the most convenient terms and competitive pricing provided.
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- Drag, M.; Salvesen, G. S. Emerging Principles in Protease-Based Drug Discovery. Nature Reviews Drug Discovery. Nature Publishing Group 2010, pp 690–701. https://doi.org/10.1038/nrd3053.