Protein-Protein Interactions (PPI) Screening Libraries

Protein-protein interactions (PPIs) are involved in important biological processes in living organisms, and their regulation can be crucial for the treatment of numerous diseases [1]. In this context, PPIs are an attractive emerging class of molecular targets and are critically important in the progression of many disease states [1,2]. PPI inhibition with small molecules is a tremendously important diagnostic and therapeutic strategy that may lead to greatly protracted remissions and even curative therapies for a number of diseases [2].

Life Chemicals offers a proprietary collection of potential PPI modulators. PPI-focused screening compounds were selected by both ligand-based (2D fingerprint similarity search, decision tree method) and receptor-based (molecular docking, high-throughput virtual screening) approaches.

References

  1. Mabonga L, Kappo AP. Protein-protein interaction modulators: advances, successes and remaining challenges. Biophys Rev. 2019;11(4):559-581. 
  2. Macalino SJY, Basith S, Clavio NAB, Chang H, Kang S, Choi S. Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery. Molecules. 2018;23(8):1963. 
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