Protein phosphorylation is vital for normal cellular function, as it is a major control mechanism of a wide range of physiological processes. Phosphatases are enzymes that catalyze the dephosphorylation process. These enzymes replace a phosphate group in a substrate with a hydroxyl group from activation water. The action of phosphatases is directly opposite to that of phosphorylases and kinases. They play a significant role in signal transduction pathways and control a vast variety of cellular processes, including metabolism, gene transcription and translation, cell-cycle progression, cytoskeletal rearrangement, protein-protein interactions (PPI), protein stability, cell movement, and apoptosis.
At Life Chemicals, we have designed several proprietary Phosphatase-related Screening Libraries of drug-like screening compounds, carefully selected by computational chemistry methods to boost phosphatase-targeted drug discovery:
- ligand-based drug design (2D fingerprint similarity search)
- receptor-based drug design (molecular docking, high-throughput virtual screening, de novo protein reconstruction)
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The compound selection can be customized based on your requirements, cherry picking is available.
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