Protein kinases are the second most investigated group of drug target after the G-protein-coupled receptors. The majority (67%) of the kinases belong to the serine/threonine protein kinases (STK), and 17% belong to tyrosine protein kinases.
Kinase inhibition has been shown to play an essential role in practically all major disease areas. The recent development of small-molecule kinase inhibitors for the treatment of diverse types of cancer has proven to be successful in clinical therapy. Therefore, kinase inhibitor drug discovery programs have recently broadened their focus to include an expanded range of kinase targets and therapeutic areas.
Life Chemicals has carefully selected drug-like screening molecules with predicted kinase-related inhibitory activity from the Life Chemicals HTS Compound Collection, using both ligand-based and receptor-based approaches. The resulting Screening Compound Libraries of potential kinase activity modulators aim to boost kinase-targeted drug discovery efforts.
Compound cherry-picking within each screening library is available. Custom compound selection based on specific parameters can be performed, with the most convenient terms and competitive pricing provided.
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