Cytochrome Inhibitor Library

Cytochromes 450 (CYPs) are considered to be one of the most important enzyme families involved in metabolic clearance of the vast majority of prescribed drugs and foreign chemicals to which the body is exposed. The cytochrome family members can be characterized by a common site structure with rigid conformation due to the presence of a heme group.

Life Chemicals has prepared its Cytochrome Screening Library with a 2D fingerprint similarity search approach performed against a reference set of compounds obtained from the ChEMBL database (Tanimoto index cut-off > 0.85). Over 1,900 structurally diverse screening compounds, capable of fitting the cytochrome binding site to form donor/acceptor bonds and produce CYP inhibition, were selected from the HTS Compound Collection

The list of target enzymes is shown below:

  • Cytochrome P450 1A2
  • Cytochrome P450 1A1
  • Cytochrome P450 3A4
  • Cytochrome P450 2D6
  • Cytochrome P450 19A1
  • Cytochrome P450 11B1
  • Cytochrome P450 2C9
  • Cytochrome P450 2B6
  • Cytochrome P450 2A6
  • Cytochrome P450 17A1
  • Cytochrome P450 2C19
  • Cytochrome P450 3A4/3A5
  • Cytochrome P450 51
  • Cytochrome P450 2C8
  • Cytochrome P450 11B2
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