Life Chemicals presents the General Covalent Inhibitor Library of over 10,900 compounds for covalent screening selected from the Life Chemicals HTS Compound Collection by specific structural moieties (functional groups), sometimes referred to as “warheads”, that are known to form covalent bonds with amino acid residues in binding sites of target proteins: Lys, Cys, Ser, Thr, Asp, Glu, and Tyr.
The following chemical classes and structural features were used for selection of possible covalent binding irreversible inhibitors:
The final set of small-molecule screening compounds was obtained by applying the extended Rule of Five criteria:
You can cherry-pick compounds or focus on a specific class of covalent modifiers. Separate focused sets of covalent binders targeting each of the indicated amino acid residues (Cysteine, Serine, Lysine, Tyrosine, Threonine) can be provided or request. Please, contact us at firstname.lastname@example.org for any details and quotations.
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