Autoimmune diseases are pathological conditions characterized by dysregulated inflammation against self-antigens and affect up to 10 % of the population. The conventional treatments for autoimmune diseases broadly suppress general immune function to modulate uncontrolled inflammation. Modern strategies aim at selective inhibition of key pro-inflammatory pathways to reduce pathology while preserving normal immune homeostasis. Current efforts focus on inhibiting inflammatory cytokines, cell surface receptors and intracellular kinases.
Life Chemicals is supporting this research with dedicated screening libraries specifically designed for the discovery of drugs for autoimmune and inflammatory diseases.
Our Anti-inflammatory Screening Compound Library comprises over 2,900 drug-like screening compounds predicted to target major inflammation mediators, including:
- Chemokine receptors (CCR1, CCR2, CCR3, CCR4, CCR5)
- Histamine H4 and bradykinin B1 receptors
- Cyclooxygenases (COX-1, COX-2) and Prostaglandin E synthase (PGES)
- Toll-like receptors (TLR2/6, TLR7, TLR8)
- Angiotensin II receptor subtypes
- Kinases PI3K, JAK3, SK1, SYK, LRRK2
Beyond anti-inflammatory targets, Life Chemicals portfolio includes focused sets that address complementary mechanisms relevant to autoimmune pathogenesis:
- Immuno-oncology Screening Libraries: 3,700 potential modulators of immune checkpoints and T-cell activation pathways
- Epigenetic Screening Libraries: over 14,000 screening compounds that are potential inhibitors of histone-modifying enzymes and other epigenetic molecular targets and complexes
- Apoptosis Signaling Pathway Screening Library: 26,800 drug-like compounds potentially targeting apoptotic proteins, regulating programmed cell death in immune cells
- Celiac Disease Screening Library: 1,200 predicted TG2 inhibitors for gluten-induced autoimmunity
Additionally, we offer screening sets dealing with targets related to autoimmune disease drug discovery:
- Tyrosine Kinase Screening Library: 5,700 potential inhibitors of kinases implicated in immune cell activation and signaling
- Serine Protease Screening Libraries: screening compounds targeting proteases involved in inflammatory cascades
- Phosphatase Focused Libraries: molecules aiming at PTP family members regulating immune receptor signaling
- STING-targeting Screening Library: 2,600 compounds modulating the cGAS-STING pathway for innate immunity regulation
- Deubiquitinase Screening Libraries: contains targets involved in protein degradation and immune signaling
All Screening Sets are optimized for high-throughput and phenotypic assays, providing powerful platforms to identify novel leads for rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes, psoriasis, and other autoimmune indications.
Contact our team at markerting@lifechemicals.com to design a custom screening set for your next drug discovery project in autoimmune diseases!