The Company’s cheminformatics team has successfully developed a significantly increased collection of unique Kinase Targeted Libraries now containing over 30,000 screening compounds. These Libraries, prepared by a receptor-based approach with the use of our proprietary HTS Compound Collection, will undoubtedly provide new exceptional resources to the drug discovery of small-molecule kinase inhibitors.
Several Computational Chemistry Methods were applied: reference compounds set selection and analysis, in silico high-throughput screening (HTS), homology modeling, molecular dynamics, molecular docking, etc. Also, the crystal 3D structures of protein-ligand complexes of molecular targets from different kinase families were used.
Presented below is the whole list of the Libraries updated:
- AKT Serine/threonine Kinase Targeted Library
- ALK Tyrosine Kinase Focused Library
- Aurora A Kinase Targeted Library
- Aurora B Kinase Targeted Library
- c-AMP Dependent Protein Kinase (PKA) Targeted Library
- c-Met (HGFR) Kinase Targeted Library
- Cyclin-dependent Kinase Screening Libraries
- Diacylglycerol Kinase (DGK) Screening Library
- ERK5 (MAPK7) Kinase Targeted Library
- Fes/c-Fes Tyrosine Protein Kinase Targeted Library
- Fibroblast Growth Factor Receptor 1 Tyrosine Kinase Targeted Library
- Janus Kinase (JAK) Targeted Library
- 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Targeted Library
- p38 Mitogen-activated Protein (MAP) Kinase Focused Library
- Phosphatidylinositol 3-Kinase (PI3K) Targeted Library
- ROCK Kinase Targeted Library
- Vascular Endothelial Growth Factor Receptor Kinase 2 (VGFR-2) Focused Library
Furthermore, , an extensive selection of potential kinase activity modulators can be found in our ligand-based kinase-focused screening libraries:
- Kinase Focused Library
- Kinase Screening Library (KSL)
- Kinase Targeted Library by Docking
- Tyrosine Kinase Screening Library
The compound selection can be customized based on your requirements, cherry picking is available.
Please, contact us at orders@lifechemicals.com for any additional information and price quotations.
