Myosins play essential roles in muscle contraction, cell motility, intracellular transport and cytokinesis. Dysregulation of myosin function has been implicated in cardiovascular diseases, cancer, fibrosis, neurological disorders and other pathologies, making myosin proteins attractive therapeutic targets.
Recent clinical advances in cardiac myosin inhibition have renewed interest in discovering selective modulators of additional myosin isoforms for cardiovascular, oncology and neuromuscular applications.
Our Original Screening Libraries
To support this rapidly expanding field, Life Chemicals has developed its new screening libraries containing carefully selected small molecules with a pronounced potential to modulate diverse myosin isoforms:
- 1,200 drug-like compounds available from stock
- Designed using ligand-based approaches and experimentally validated myosin inhibitors
- Suitable for primary HTS campaigns, hit identification and early SAR studies
- 2,000 screening compounds, synthesizable on request
- Designed using structure-based methods targeting Myosin-2 and β-cardiac Myosin-7
- Optimized for selective hit discovery and target-focused screening
Featuring our advantages:
- Drug-like compounds suitable for medicinal chemistry optimization
- Diverse chemotypes to maximize hit discovery opportunities
- Designed using advanced computational and medicinal chemistry approaches
- Flexible formats, including cherry-picking and custom-tailored screening sets
Start your myosin-pointed drug discovery with Life Chemicals compounds!
Please, contact us at marketing@lifechemicals.com for versatile collaboration prospects.