We present our original and brand-new Cys-focused Diversity Screening Set as a convenient starting point for covalent screening in drug discovery projects.
The entire Library of Cysteine Focused Covalent Inhibitors of almost 14,000 potential cysteine covalent binders was refined by means of modern machine learning methods and diversity filtering to select over 3,800 most-promising screening compounds that could react with cysteine residues of a drug target reversibly or irreversibly.
- Novel screening compounds synthesized in-house
- Cherry-picking and chemoinformatics assistance
- Only drug-like molecules: the Lipinski's Rule of Five and Veber criteria compliant
- No PAINS (A, B, C families), toxic, reactive, and unstable compounds
- Over 90 % purity confirmed by LCMS and/or NMR data
- Hit re-supply, product scale-up
- Compound library design, combinatorial synthesis based on found hits
- Competitive pricing and convenient terms
Please, contact us at email@example.com for any additional information and price quotations.