The design, structural optimization and synthesis of novel dual inhibitors targeting the SARS-CoV-2 main protease (Mpro) and papain-like protease (PLpro) were reported by the Life Chemicals team in our new publication in Current Chemistry Letters. Taking into account a previously identified quinolinone-based lead, the study describes rational scaffold optimization, structure-affinity analysis and the generation of a focused compound library. Docking studies indicate favorable binding to both protease active sites, along with promising ADME properties predicted. Thus, the study presented has established a solid foundation for subsequent in vitro evaluation of these dual non-covalent inhibitors.
Current Chemistry Letters 15 (2026) 251–262
DOI: 10.26434/chemrxiv-2025-v08qq
Please refer to Publications by Life Chemicals team for the whole selection.
Application of Life Chemicals products is illustrated by our customers in Publications citing Life Chemicals product.
Contact us at marketing@lifechemicals.com or versatile collaboration prospects.