Computational Chemistry

Phenotypic and target-based HTS in drug discovery

Given the complementary benefits and capabilities of the two screening methods, Life Chemicals considers both approaches for creating the most diverse and balanced collection of screening compound libraries for HTS efforts in drug discovery.

Read more
09 december 2022, 17:08    Svitlana Kondovych Computational Chemistry

Advantages of 3D-shape of ligands in drug discovery

Rapidly developing structure-based drug design (SBDD) is mainly based on various computational techniques, which allow for the automation and acceleration of the drug design workflow. Life Chemicals offers its proprietary collection of 3D-shaped and Fsp3-enriched screening compounds for efficient drug discovery.

Read more
07 september 2022, 15:22    Svitlana Kondovych Computational Chemistry

Measuring Structural Diversity for Screening Compound Libraries

Research efforts that seek to prioritize the selection of screening compound libraries or sub-libraries for experimental evaluation can take advantage of chemical diversity to increase the probability of finding new scaffolds.

Read more
27 july 2022, 17:23    Andrew Golub Computational Chemistry

Compound solubility measurements for early drug discovery

Solubility affects various physicochemical characteristics of compounds, such as adsorption and bioavailability, hence solubility data is critical for the successful flow of drug development studies.

Read more
31 may 2022, 13:06    Svitlana Kondovych Computational Chemistry

Importance of ADME/Tox in Early Drug Discovery

The drug candidates have a high attrition rate as they often fail to show the anticipated efficacy, or are found to pose unacceptable risks to human health. This is why studying ADME/Tox is crucial in drug discovery and development. At Life Chemicals, we provide an array of In Vitro ADMET Tests as a part of our early drug discovery portfolio.

Read more
21 january 2022, 16:18    Andrew Golub Computational Chemistry
This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. By using our website, you accept our conditions of use of cookies to track data and create content (including advertising) based on your interest. Accept