Phenotypic and target-based HTS in drug discovery
Given the complementary benefits and capabilities of the two screening methods, Life Chemicals considers both approaches for creating the most diverse and balanced collection of screening compound libraries for HTS efforts in drug discovery.
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Advantages of 3D-shape of ligands in drug discovery
Rapidly developing structure-based drug design (SBDD) is mainly based on various computational techniques, which allow for the automation and acceleration of the drug design workflow. Life Chemicals offers its proprietary collection of 3D-shaped and Fsp3-enriched screening compounds for efficient drug discovery.
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Measuring Structural Diversity for Screening Compound Libraries
Research efforts that seek to prioritize the selection of screening compound libraries or sub-libraries for experimental evaluation can take advantage of chemical diversity to increase the probability of finding new scaffolds.
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Compound solubility measurements for early drug discovery
Solubility affects various physicochemical characteristics of compounds, such as adsorption and bioavailability, hence solubility data is critical for the successful flow of drug development studies.
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Importance of ADME/Tox in Early Drug Discovery
The drug candidates have a high attrition rate as they often fail to show the anticipated efficacy, or are found to pose unacceptable risks to human health. This is why studying ADME/Tox is crucial in drug discovery and development. At Life Chemicals, we provide an array of In Vitro ADMET Tests as a part of our early drug discovery portfolio.
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