Computational Chemistry

The ultimate goal of defeating HIV and AIDS motivates the continuous search for novel medicines and strategies. To support the promising course of small-molecule drug design for antiretroviral treatment, Life Chemicals offers a set of Anti-HIV Screening Libraries.

Protein-protein interactions are promising but challenging druggable targets for novel drug discovery. Recently, effective small-molecule inhibitors have been discovered for several important PPIs. Herein, Life Chemicals presents its updated PPI Screening Libraries of potential small-molecule drug-like PPI inhibitors.

Alzheimer’s disease is one of the most obstinate medical problems. Existing medications fail to stop the progression of dementia, and numerous drug discovery programs have shown low success rates. Life Chemicals offers CNS-related Screening Libraries and a dedicated Alzheimer’s Targeted Compound Set to support Alzheimer’s drug development programs.

Lymphoma is a blood cancer caused by the rampant growth of white blood cells. In response to World Lymphoma Awareness Day 2020, Life Chemicals presents the Lymphoma-targeted Set, Anticancer Library and a collection of small molecules for HTS drug discovery against cancer-related targets.

The most significant factor that constrains the discovery of new CNS drugs is the limited blood-brain barrier penetrability. Among the most widely employed techniques to explain and predict CNS-related pharmacokinetic properties are the CNS multiparameter optimization (MPO) and the “Golden Triangle” rule.