Computational Chemistry

Peptidomimetics in Modern Drug Discovery

Peptidomimetics are synthetic molecules created to mimic natural peptides in three-dimensional form so that they retain the same biological activity while reducing the risks of their natural counterparts, including stability, proteolysis resistance, and bioavailability.

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15 september 2021, 16:41    Andrew Golub Computational Chemistry

Covalent Inhibitors as Potent Drugs in Pharmaceutical Industry

Covalent modifiers are crucial to the development of new drugs. Approximately 30% of all marketed drugs act as covalent inhibitors today. Despite the initial concerns about potential off-target toxicity, covalent inhibitors offer numerous advantages. In this way, there is continuous research, especially on cancer targets.

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28 july 2021, 13:21    Andrew Golub Computational Chemistry

Fragment-based Screening Methods for Innovative Drug Discovery

Highly sensitive methods for hit detection in FBDD are an absolute must. FBDD applies various biochemical, biophysical, and computational techniques to efficiently identify the event of weak fragment binding to a specific protein target. Life Chemicals offers a proprietary collection of Fragment Libraries to support these drug discovery efforts.

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23 june 2021, 09:35    Svitlana Kondovych Computational Chemistry

Metal Chelation in Enzyme Active Sites for Drug Discovery

Metalloenzyme inhibitors form one of the most promising medication classes used to treat various pathologies, including cancer, viral and bacterial infections, neurodegenerative and other diseases. Life Chemicals is offering several screening compound libraries of small organic molecules that serve as potential chelating ligands.

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12 may 2021, 15:11    Svitlana Kondovych Computational Chemistry

Key Events in Epigenetic Drug Discovery

Epigenetics is an exciting research field with vast clinical implications. At Life Chemicals, we have recently updated and re-designed our Epigenetic Targeted and Focused Libraries with an emphasis on most-promising epigenetic-related targets and ligands in response to epigenetic drug discovery trends.

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12 april 2021, 17:21    Andrew Golub Computational Chemistry
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