The structural unit of substituted pyridines is present in quite a few widely occurring compounds, including natural products, such as vitamins, coenzymes, and alkaloids, as well as synthetic pharmaceuticals and agrochemicals . As shown in Figure 1, natural compounds containing pyridine rings include nicotinamide 1, pyridoxol (vitamin B6) 2, and the opium alkaloid papaverine 3 used as a muscle relaxant and vasodilator.
Figure 1. Examples of naturally occurring pyridine derivatives.
Pyridine, after piperidine, is the second most common nitrogen heterocycle, appearing in 62 FDA-approved drugs [2-3]. A few examples of the approved pyridine-based drugs are given in Figure 2. In particular, Torasemide 4 in which the pyridine unit is combined with the sulfo urea is an efficient antihypertensive drug. Pyridostigmine 5 is used in the treatment of myasthenia gravis and to reverse the actions of muscle relaxants. Alendronic acid 6 is a bisphosphonate that is a known medication to defeat various forms of osteoporosis, whereas Vismodegib 7 is applied as an anti-carcinoma drug.
Figure 2. Examples of FDA-approved drugs bearing pyridine substructure.
Shown below are representatives of the pyridine-containing building blocks available from Life Chemicals.
The full list of the functionalized pyridines can be obtained upon request by emailing email@example.com.
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