Building Blocks

Bioactive Compounds and Materials Based on Functionalized 1,3,4-Oxadiazoles

A number of the 1,3,4-oxadiazoles have shown a very broad spectrum of biological activity: anti-cancer activity, inhibitors of various enzymes, herbicides, antifungal activity.

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07 november 2022, 15:41    Oleg Lukin Building Blocks

Functionalized 1,3,4-Thiadiazoles for Various Applications in Drug Discovery, Agrochemistry, and Materials Technology

Derivatives of 1,3,4-thiadiazoles possess a wide spectrum of biological activity and have found numerous applications in medicine, agriculture, and materials technology.

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04 july 2022, 12:46    Oleg Lukin Building Blocks

Substituted Azetidines in Drug Discovery

Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities. Presently ca. 60 approved and over 30 experimental drugs bear the moiety of azetidine-2-one.

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12 april 2022, 16:35    Oleg Lukin Building Blocks

Explore Our Hetaryl-tethered Natural Derivatives of Chromone and Coumarin

Natural products bearing chromone and coumarin substructures possess a broad spectrum of biological activities by altering the catalytic function of numerous enzymatic reactions. Life Chemicals offer hetaryl-tethered natural derivatives of chromone and coumarin for organic synthesis and medicinal chemistry projects.

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15 february 2022, 12:59    Oleg Lukin Building Blocks

Functionalized (-)-Cytisine Derivatives for Medicinal Chemistry and Organic Synthesis

Naturally occurring alkaloid ()-cytisine is an efficient acetylcholine agonist possessing a strong affinity to nicotinic acetylcholine receptors (nAChRs). Its various chemical modifications were applied to obtain novel bicyclic compounds for rational drug discovery. Life Chemicals offers derivatives of ()-cytisine including those involving chromone, coumarin, and other heterocyclic substructures.

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10 november 2021, 13:26    Oleg Lukin Building Blocks
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