Building Blocks

Conformationally restricted amino acids and peptides in which conformational freedom is substantially reduced by the presence of small rings have assumed a prominent role in drug design and development. They are used in the peptidomimetic drug design as surrogates of proline.

Pyrrolidines are an important class of heterocycles found in numerous natural products, bioactive molecules and organocatalysts. In view of this, Life Chemicals designed its original pyrrolidine-based building blocks to inspire organic synthesis and medicinal chemistry projects.

The structural unit of substituted pyridazine is present in many biologically active compounds and a lot of research is now focused on the synthesis of novel pyridazine-based building blocks and combinatorial libraries.

Pyrazine substructure is present in many biologically and technologically relevant compounds. Substituted pyrazines are widely used as pharmaceuticals, while pyrazine-based polymers and other light-responsive materials are of high interest for technological applications.

Pyrimidine derivatives are by far the most important compounds in living organisms, including subunits of RNA, DNA and many natural antibiotics. Despite a large number of marketed pyrimidine-based drugs and agrochemicals, functionalized pyrimidines are still heavily employed as building blocks in drug discovery programs.