Building Blocks

Functionalized 1,3,4-Thiadiazoles for Various Applications in Drug Discovery, Agrochemistry, and Materials Technology

Derivatives of 1,3,4-thiadiazoles possess a wide spectrum of biological activity and have found numerous applications in medicine, agriculture, and materials technology.

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04 july 2022, 12:46    Oleg Lukin Building Blocks

Substituted Azetidines in Drug Discovery

Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities. Presently ca. 60 approved and over 30 experimental drugs bear the moiety of azetidine-2-one.

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12 april 2022, 16:35    Oleg Lukin Building Blocks

Explore Our Hetaryl-tethered Natural Derivatives of Chromone and Coumarin

Natural products bearing chromone and coumarin substructures possess a broad spectrum of biological activities by altering the catalytic function of numerous enzymatic reactions. Life Chemicals offer hetaryl-tethered natural derivatives of chromone and coumarin for organic synthesis and medicinal chemistry projects.

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15 february 2022, 12:59    Oleg Lukin Building Blocks

Functionalized (-)-Cytisine Derivatives for Medicinal Chemistry and Organic Synthesis

Naturally occurring alkaloid ()-cytisine is an efficient acetylcholine agonist possessing a strong affinity to nicotinic acetylcholine receptors (nAChRs). Its various chemical modifications were applied to obtain novel bicyclic compounds for rational drug discovery. Life Chemicals offers derivatives of ()-cytisine including those involving chromone, coumarin, and other heterocyclic substructures.

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10 november 2021, 13:26    Oleg Lukin Building Blocks

Functionalized Pyridines as Valuable Building Blocks in Organic Synthesis and Medicinal Chemistry

The structural unit of substituted pyridine occurs in numerous important compounds including natural products such as vitamins, coenzymes, and alkaloids as well as synthetic pharmaceuticals and agrochemicals.

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12 october 2021, 16:29    Oleg Lukin Building Blocks
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