Building Blocks

Piperidine-based building blocks have found extensive application in medicinal chemistry. The piperidine substructure is also present in a variety of biologically active natural products, synthetic pharmaceuticals, and agrochemicals. Life Chemicals offers a selection of functionalized C-substituted piperidines.

Small and lipophilic cyclopropane rings are finding increasingly sophisticated use in pharmaceuticals. We offer a proprietary collection of subsituted cyclopropane derivatives for intorduction of conformational constraints into small molecules and peptide ligands in drug discovery efforts.

The structural unit of substituted 1,3-thiazole is ubiquitous in natural products and synthetic materials, while thiazole moiety is a privileged scaffold in drug discovery.

Сyclobutanes are heavily exploited in organic synthesis as subunits for natural product preparation, ring-opening, and ring-contraction reactions. In medicinal chemistry, the introduction of a cyclobutane fragment is often used to achieve a conformational restriction.

Azepane derivatives attract considerable attention in organic synthesis and drug discovery. There are several naturally occurring azepane derivatives possessing a number of biological activities.