Building Blocks

Explore Our Novel Cyclobutane Derivatives

Сyclobutanes are heavily exploited in organic synthesis as subunits for natural product preparation, ring-opening, and ring-contraction reactions. In medicinal chemistry, the introduction of a cyclobutane fragment is often used to achieve a conformational restriction.

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14 december 2020, 17:28    Oleg Lukin Building Blocks

C-Substituted Azepanes for Novel Organic Synthesis and Drug Discovery Research

Azepane derivatives attract considerable attention in organic synthesis and drug discovery. There are several naturally occurring azepane derivatives possessing a number of biological activities.

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12 november 2020, 12:19    Oleg Lukin Building Blocks

Expand Your Building Block Collection with Our Functionalized 1,3-Oxazoles

A large number of substituted oxazole-containing natural products have been isolated, mostly from marine microorganisms. Many of these natural products are structurally complex and of considerable biological interest.

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30 june 2020, 17:15    Oleg Lukin Building Blocks

Explore Our Functionalized 1,2,3-Triazoles for Diverse Applications

1,2,3-Triazoles are important structural motifs in diverse research fields, ranging from medicinal chemistry and agriculture to materials science. These heterocycles have proved very valuable as isostere of the amide group in bioactive molecules on account of their remarkable metabolic stability.

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02 june 2020, 18:34    Oleg Lukin Building Blocks

Novel Conformationally Restricted Amino Acids for Peptidomimetic Drug Design

Conformationally restricted amino acids and peptides in which conformational freedom is substantially reduced by the presence of small rings have assumed a prominent role in drug design and development. They are used in the peptidomimetic drug design as surrogates of proline.

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18 february 2020, 17:18    Oleg Lukin Building Blocks
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