Building Blocks

Substituted Azetidines in Drug Discovery

Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities. Presently ca. 60 approved and over 30 experimental drugs bear the moiety of azetidine-2-one.

Read more
12 april 2022, 16:35    Oleg Lukin Building Blocks

Explore Our Hetaryl-tethered Natural Derivatives of Chromone and Coumarin

Natural products bearing chromone and coumarin substructures possess a broad spectrum of biological activities by altering the catalytic function of numerous enzymatic reactions. Life Chemicals offer hetaryl-tethered natural derivatives of chromone and coumarin for organic synthesis and medicinal chemistry projects.

Read more
15 february 2022, 12:59    Oleg Lukin Building Blocks

Functionalized (-)-Cytisine Derivatives for Medicinal Chemistry and Organic Synthesis

Naturally occurring alkaloid ()-cytisine is an efficient acetylcholine agonist possessing a strong affinity to nicotinic acetylcholine receptors (nAChRs). Its various chemical modifications were applied to obtain novel bicyclic compounds for rational drug discovery. Life Chemicals offers derivatives of ()-cytisine including those involving chromone, coumarin, and other heterocyclic substructures.

Read more
10 november 2021, 13:26    Oleg Lukin Building Blocks

Functionalized Pyridines as Valuable Building Blocks in Organic Synthesis and Medicinal Chemistry

The structural unit of substituted pyridine occurs in numerous important compounds including natural products such as vitamins, coenzymes, and alkaloids as well as synthetic pharmaceuticals and agrochemicals.

Read more
12 october 2021, 16:29    Oleg Lukin Building Blocks

Conformationally Restricted Diamines in Medicinal Chemistry and Drug Discovery

Conformationally restricted diamines (CRDAs) are especially attractive scaffolds for drug discovery because they offer the potential of the wide variability in the relative spatial arrangement of functional groups.

Read more
26 august 2021, 14:22    Oleg Lukin Building Blocks
This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. By using our website, you accept our conditions of use of cookies to track data and create content (including advertising) based on your interest. Accept