Building Blocks

Functionalized Pyridines as Valuable Building Blocks in Organic Synthesis and Medicinal Chemistry

The structural unit of substituted pyridine occurs in numerous important compounds including natural products such as vitamins, coenzymes, and alkaloids as well as synthetic pharmaceuticals and agrochemicals.

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12 october 2021, 16:29    Oleg Lukin Building Blocks

Conformationally Restricted Diamines in Medicinal Chemistry and Drug Discovery

Conformationally restricted diamines (CRDAs) are especially attractive scaffolds for drug discovery because they offer the potential of the wide variability in the relative spatial arrangement of functional groups.

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26 august 2021, 14:22    Oleg Lukin Building Blocks

1,2,4-Oxadiazole Derivatives to Power Up Your Research

1,2,4-oxadiazole moiety is used in peptidomimetics, a stable isostere of ester and amide functionalities. The 1,2,4-oxadiazoles are promising building blocks in organic synthesis, drug discovery and materials science.

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06 july 2021, 17:54    Oleg Lukin Building Blocks

Functionalized Isoxazoles to Augment Your Building Block Collection

Isoxazole derivatives are versatile synthetic building blocks due to their dormant functionalities. The substituted isoxazole unit is present in several natural products, synthetic drugs, and other biologically active compounds.

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08 june 2021, 13:58    Oleg Lukin Building Blocks

Expand your building block collection with our C-Substituted Morpholines

Morpholines and their homologs are highly represented among small molecules that are biologically and therapeutically relevant, including many natural products. Morpholine scaffolds have also been widely utilized in the agrochemical industry and as chiral auxiliaries in asymmetric synthesis.

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26 april 2021, 15:40    Oleg Lukin Building Blocks
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