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Bioactive Compounds and Materials Based on Functionalized 1,3,4-Oxadiazoles

A number of the 1,3,4-oxadiazoles have shown a very broad spectrum of biological activity: anti-cancer activity, inhibitors of various enzymes, herbicides, antifungal activity.

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07 november 2022, 15:41    Oleg Lukin Building Blocks

Advantages of 3D-shape of ligands in drug discovery

Rapidly developing structure-based drug design (SBDD) is mainly based on various computational techniques, which allow for the automation and acceleration of the drug design workflow. Life Chemicals offers its proprietary collection of 3D-shaped and Fsp3-enriched screening compounds for efficient drug discovery.

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07 september 2022, 15:22    Svitlana Kondovych Computational Chemistry

Measuring Structural Diversity for Screening Compound Libraries

Research efforts that seek to prioritize the selection of screening compound libraries or sub-libraries for experimental evaluation can take advantage of chemical diversity to increase the probability of finding new scaffolds.

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27 july 2022, 17:23    Andrew Golub Computational Chemistry

Functionalized 1,3,4-Thiadiazoles for Various Applications in Drug Discovery, Agrochemistry, and Materials Technology

Derivatives of 1,3,4-thiadiazoles possess a wide spectrum of biological activity and have found numerous applications in medicine, agriculture, and materials technology.

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04 july 2022, 12:46    Oleg Lukin Building Blocks

Compound solubility measurements for early drug discovery

Solubility affects various physicochemical characteristics of compounds, such as adsorption and bioavailability, hence solubility data is critical for the successful flow of drug development studies.

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31 may 2022, 13:06    Svitlana Kondovych Computational Chemistry
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