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C-Substituted Azepanes for Novel Organic Synthesis and Drug Discovery Research

Azepane derivatives attract considerable attention in organic synthesis and drug discovery. There are several naturally occurring azepane derivatives possessing a number of biological activities.

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12 november 2020, 12:19    Oleg Lukin Building Blocks

Protein-protein Interactions as Drug Targets

Protein-protein interactions are promising but challenging druggable targets for novel drug discovery. Recently, effective small-molecule inhibitors have been discovered for several important PPIs. Herein, Life Chemicals presents its updated PPI Screening Libraries of potential small-molecule drug-like PPI inhibitors.

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26 october 2020, 12:58    Andrew Golub Computational Chemistry

World Alzheimer’s Day 2020

Alzheimer’s disease is one of the most obstinate medical problems. Existing medications fail to stop the progression of dementia, and numerous drug discovery programs have shown low success rates. Life Chemicals offers CNS-related Screening Libraries and a dedicated Alzheimer’s Targeted Compound Set to support Alzheimer’s drug development programs.

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21 september 2020, 11:09    Svitlana Kondovych Computational Chemistry

World Lymphoma Awareness Day 2020

Lymphoma is a blood cancer caused by the rampant growth of white blood cells. In response to World Lymphoma Awareness Day 2020, Life Chemicals presents the Lymphoma-targeted Set, Anticancer Library and a collection of small molecules for HTS drug discovery against cancer-related targets.

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14 september 2020, 15:01    Svitlana Kondovych Computational Chemistry

Using Descriptor Cutoffs and Multiparameter Optimization for Preparation of CNS Targeted Libraries

The most significant factor that constrains the discovery of new CNS drugs is the limited blood-brain barrier penetrability. Among the most widely employed techniques to explain and predict CNS-related pharmacokinetic properties are the CNS multiparameter optimization (MPO) and the “Golden Triangle” rule.

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01 september 2020, 12:11    Svitlana Kondovych Computational Chemistry
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