Peptidomimetics in Modern Drug Discovery

Peptidomimetics are synthetic molecules created to mimic natural peptides in three-dimensional form so that they retain the same biological activity while reducing the risks of their natural counterparts, including stability, proteolysis resistance, and bioavailability.

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15 september 2021, 16:41    Andrew Golub Computational Chemistry

Conformationally Restricted Diamines in Medicinal Chemistry and Drug Discovery

Conformationally restricted diamines (CRDAs) are especially attractive scaffolds for drug discovery because they offer the potential of the wide variability in the relative spatial arrangement of functional groups.

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26 august 2021, 14:22    Oleg Lukin Building Blocks

Covalent Inhibitors as Potent Drugs in Pharmaceutical Industry

Covalent modifiers are crucial to the development of new drugs. Approximately 30% of all marketed drugs act as covalent inhibitors today. Despite the initial concerns about potential off-target toxicity, covalent inhibitors offer numerous advantages. In this way, there is continuous research, especially on cancer targets.

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28 july 2021, 13:21    Andrew Golub Computational Chemistry

1,2,4-Oxadiazole Derivatives to Power Up Your Research

1,2,4-oxadiazole moiety is used in peptidomimetics, a stable isostere of ester and amide functionalities. The 1,2,4-oxadiazoles are promising building blocks in organic synthesis, drug discovery and materials science.

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06 july 2021, 17:54    Oleg Lukin Building Blocks

Fragment-based Screening Methods for Innovative Drug Discovery

Highly sensitive methods for hit detection in FBDD are an absolute must. FBDD applies various biochemical, biophysical, and computational techniques to efficiently identify the event of weak fragment binding to a specific protein target. Life Chemicals offers a proprietary collection of Fragment Libraries to support these drug discovery efforts.

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23 june 2021, 09:35    Svitlana Kondovych Computational Chemistry
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