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Novel Conformationally Restricted Amino Acids for Peptidomimetic Drug Design

Conformationally restricted amino acids and peptides in which conformational freedom is substantially reduced by the presence of small rings have assumed a prominent role in drug design and development. They are used in the peptidomimetic drug design as surrogates of proline.

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Yesterday at 17:18    Oleg Lukin Building Blocks 0    0    0

World Cancer Day 2020: “I Am and I Will”

2020 marks the midway point of the 3-year ‘I Am and I Will’ campaign, an empowering call-to-action urging for personal commitment and represents the power of individual action taken now to impact the future. Supporting the World Cancer Day initiative, Life Chemicals offers a featured list of its cancer therapy-related products (Targeted and Focused Libraries).

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31 january 2020, 15:50    Andrew Golub Computational Chemistry 0    0    0

Diversity-based Screening of Compound Libraries in Drug Discovery

High-throughput screening (HTS) allowed rapid bioactivity profile exploration of large compound libraries in order to improve the chances of identifying (diverse) hits for further investigation. The diversity-based library design attempts to explore appropriate chemical space by optimizing biological relevance and compound diversity in order to provide multiple starting points for further hit/lead development

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28 january 2020, 16:30    Andrew Golub Computational Chemistry 0    0    0

C-Substituted Pyrrolidines from Life Chemicals Inspiring Your Drug Discovery Endeavour!

Pyrrolidines are an important class of heterocycles found in numerous natural products, bioactive molecules and organocatalysts. In view of this, Life Chemicals designed its original pyrrolidine-based building blocks to inspire organic synthesis and medicinal chemistry projects.

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07 january 2020, 18:59    Oleg Lukin Building Blocks 0    0    0

Take a Closer Look at Our Original Functionalized Pyridazines!

The structural unit of substituted pyridazine is present in many biologically active compounds and a lot of research is now focused on the synthesis of novel pyridazine-based building blocks and combinatorial libraries.

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10 december 2019, 12:05    Oleg Lukin Building Blocks 0    0    0