Compound solubility measurements for early drug discovery

Solubility affects various physicochemical characteristics of compounds, such as adsorption and bioavailability, hence solubility data is critical for the successful flow of drug development studies.

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31 may 2022, 13:06    Svitlana Kondovych Computational Chemistry

Substituted Azetidines in Drug Discovery

Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities. Presently ca. 60 approved and over 30 experimental drugs bear the moiety of azetidine-2-one.

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12 april 2022, 16:35    Oleg Lukin Building Blocks

Explore Our Hetaryl-tethered Natural Derivatives of Chromone and Coumarin

Natural products bearing chromone and coumarin substructures possess a broad spectrum of biological activities by altering the catalytic function of numerous enzymatic reactions. Life Chemicals offer hetaryl-tethered natural derivatives of chromone and coumarin for organic synthesis and medicinal chemistry projects.

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15 february 2022, 12:59    Oleg Lukin Building Blocks

Importance of ADME/Tox in Early Drug Discovery

The drug candidates have a high attrition rate as they often fail to show the anticipated efficacy, or are found to pose unacceptable risks to human health. This is why studying ADME/Tox is crucial in drug discovery and development. At Life Chemicals, we provide an array of In Vitro ADMET Tests as a part of our early drug discovery portfolio.

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21 january 2022, 16:18    Andrew Golub Computational Chemistry

Fragment-based Lead Preparation in Drug Discovery and Development

FBDD is a powerful approach in drug design. To identify the fragment hits, various screening methods are employed. Transformation of the promising fragments into larger ligands with higher affinity and activity against the target (hit-to-lead optimization) can be realized via several strategies.

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09 december 2021, 14:29    Svitlana Kondovych Computational Chemistry
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