Antibacterial Library

The Library has been designed with similarity search carried out against a reference set of compounds possessing activity in treatment of pathogenic bacteria. Information about this activity has been gathered from the most reliable compound activity databases (ChEMBL, BindingDB).

The  resulting library included compounds with Tanimoto similarity index range 0.80 – 0.85 against the reference set which was initially filtered using activity data threshold (up to 10 μM).

The reference set included inhibitors of the following pathogenic bacteria:

  • Pseudomonas aeruginosa
  • Staphylococcus aureus subsp. aureus Mu50
  • Bacillus thermoproteolyticus
  • Mycobacterium tuberculosis
  • Escherichia coli
  • Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228)
  • Streptococcus pneumoniae R6
  • Staphylococcus aureus subsp. aureus MRSA252
  • Escherichia coli K-12
  • Staphylococcus aureus
  • Mycobacterium smegmatis
  • Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
  • Streptococcus
  • Clostridium botulinum
  • Agrobacterium tumefaciens
  • Spiroplasma monobiae
  • Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius)
  • Pseudomonas putida
  • Bacillus anthracis
  • Lactobacillus casei
  • Staphylococcus epidermidis
  • Clostridium perfringens
  • Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM4680)
  • Staphylococcus aureus (strain N315)
  • Vibrio harveyi
  • Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
  • Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)
  • Thermus aquaticus
  • Escherichia coli O26:H11 str CFSAN001629
  • Mycobacterium tuberculosis H37Rv
  • Stenotrophomonas maltophilia
  • Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
  • Yersinia pestis
  • Enterococcus faecalis (strain ATCC 700802 / V583)

More than 5,300 compounds were included into the Life Chemicals Antibacterial Library.