Key Preclinicals

Advance your product development with Key Preclinicals

The Key Preclinicals laboratory for primary drug trials provides an advanced highly-efficient and solid framework of services to companies and academic institutions involved in pharmaceutical and biotech research. Available among our products is a variety of in vitro and in vivo tests, including:

Drug safety

  • General toxicology
  • Safety pharmacology (ICH S7A and S7B)

Specific pharmacological activity

  • Antihypertensive
  • Anti-inflammatory
  • Anti-ischaemic
  • Antiarrhythmic

Drug bioavailability studies

In vitro and in vivo ADMET tests

It is generally known that the early stage of drug discovery involves ADMET screening to investigate such characteristics as solubility, permeability, microsomal stability and CYP inhibition that enable identifying metabolically stable and potent substances for further analysis.

Potency measurements are necessary to evaluate drug activity in terms of the amount required to produce an effect of the given intensity (Emax, EC50) using enzyme/cell/isolated tissue assays. The type of the assay is selected in accordance with possible mechanism of drug action and customer’s requirements. At Key Preclinicals, we offer the following spectrum of in vitro and in vivo ADMET tests:

In vitro and in vivo ADMET tests carried out by Key Preclinicals

In Vitro Metabolism

  • Metabolic stability
  • Stability in plasma and buffer

In Vivo DMPK

  • Animal Pharmacokinetics

Drug Interaction

  • CYP induction/inhibition

Permeability and transporters

  • Caco-2 permeability
  • Uptake and influx transporters

Physicochemistry and binding

  • Solubility
  • Lipophilicity (logD/P)
  • Plasma protein binding
  • Red blood cells binding
  • Tissue binding
  • Microsome/hepatocyte binding

In Vitro Toxicology

  • Cytotoxicity screening
  • Genotoxicity screening (Ames test, chromatin aberration)
  • Cardiotoxicity screening (hERG testing, Q-T interval measurement in perfused isolated Langendorff heart, drug’s anti- or proarrhythmic activity using maximal follow frequency (MFF) method which refers to the sequence of consecutive contractions of the papillary muscle following each electrical stimulus)

Additionally, a range of microbiological studies can also be provided

  • Screening of potentially active antibacterial and antifungal drugs
  • Investigation of susceptibility/resistance of microorganisms to antibiotics and antifungal drugs
  • Studies of antibiofilm activity of drugs on different surfaces
  • Evaluation of potential drug activity on animal model of sepsis, cutaneous surgical and burn wounds, subcutaneous abscesses and conjunctivitis

We would be happy to facilitate your drug discovery project of any kind by contributing with our wide range of tests and top-notch expertise. Please contact us at:

Anatoly Soloviev, Prof, DSc, MD, PhD
Head of Laboratory
Phone/Fax (direct): +38 044 536 1341
Phone (office): +38 044 456 0288
Cell Phone: +38 050 445 57 69
e-mail: Anatoly.Soloviev@keypreclinicals.com

Andrew Golub, PhD
Medicinal Chemist
Representative in North America
Phone: +1 (800) 401 1533
e-mail: Andrew.Golub@keypreclinicals.com