A Reputable Partner in Custom Organic Synthesis
Looking for a dependable partner in custom organic synthesis? No doubt! For over 30 years, we have provided comprehensive custom synthesis services to support drug discovery, medicinal chemistry, and materials science. As a well-established contract research organization (CRO), Life Chemicals has successfully fulfilled various pioneering projects for leading pharmaceutical, biotech, and agrochemical companies worldwide based on fixed contracted prices and FTE models.
Whether you need an individual compound or prefer a long-term collaboration, we are committed to delivering high-quality, time- and cost-effective approaches to tackle your projects.
Our bright R&D solutions are designed for you and around you!
Contact us today at orders@lifechemicals.com and obtain optimal clues to solve your research tasks.
Comprehensive Custom Synthesis Solutions
Our experienced synthetic chemists can confidently carry out custom synthesis of a wide range of small-molecule compounds, including:
- Building blocks, starting materials, and intermediates
- Drug-like screening compounds
- Compound libraries for hit-to-lead (H2L) and SAR development
- Natural product derivatives and bioactive compound functionalization with covalent warheads and other moieties
- Reference compounds, inhibitors, activators, and target substrates
- Impurities, contaminants, or metabolites
- Transition metal ligands and organometallic compounds
Synthetic Chemistry Expertise
The Life Chemicals team specializes in advanced organic chemistry, with a strong focus on heterocyclic and element organic synthesis. Our expertise and state-of-the-art laboratory equipment enable us to implement the best result-oriented and advanced laboratory practices, in particular:
- Multistep organic synthesis
- Heterocyclic and organometallic chemistry
- Combinatorial and parallel synthesis
- Asymmetric synthesis and stereochemical separation
- Microwave-assisted and high-pressure reactions
- Metal-mediated catalysis and photochemistry
- Fluorination and organo-elemental compound synthesis
- Handling of gaseous, flammable, and hazardous reagents
- Specialized chemicals and macromolecules
- Peptide synthesis
Key Service Advantages
- Support for early drug discovery R&D
- Customer-tailored synthetic route development
- High-yield, low-environmental-impact methodologies
- Modern production and analytic facilities
- Strict quality control
- Confidentiality
- Cost-effective and scalable synthesis strategies
- Customizable formatting options
- Global logistics and prompt delivery
Flexible Service Models
To meet diverse research and industry needs, Life Chemicals can offer its customers one of the following contract terms:
- Fee-for-Service (FFS) projects
- Full-Time Equivalent (FTE) models
Early Drug Discovery Services
Supporting research projects in medicinal chemistry, Life Chemicals provides early-stage drug discovery services, including:
- Hit and lead optimization
- Product scale-up
- Reaction and process optimization
- Catalyst screening and optimization
- Peptidomimetics design, synthesis, and characterization
- Customizable quality assurance services
- Characterization of physical and chemical properties
- Analogue search and custom compound sourcing
Specialized chemicals and macromolecules
Life Chemicals can expertly perform custom synthesis of advanced functionalized building blocks and macromolecules, ensuring high precision and efficacy. In particular, our synthetic capabilities cover the following products and services:
- DNA-encoded (DEL) Reagents and Building Blocks
- Degrader Building Blocks for Targeted Protein Degradation
- Mectin-based Screening Library
- Photoaffinity Labeling (PAL) Tools: Diazirine Derivatives
- Chalcone-4’-sulfonyl Derivatives
- Spirocyclic Hybrids of Nortropane and 1,3-Oxazinan-2-one
- Task-Specific Calixarenes
- Sulfonimide-based Dendrimers
- Photochemical Synthesis
- Resorcinarene Derivatives
Synthetic Route Development and Optimization
The Company’s proficiency in synthetic route scouting for your molecules will confidently bring you the following advantages:
- Development of novel and customized synthetic routes via initial lab-scale research
- Optimization of synthetic route (e.g., higher yield, lower costs, lower environmental impact, reduction of by-products)
- Alternative synthetic routes (e.g., avoiding hazardous starting materials, blind-alley or inappropriate synthesis method, IP-protected compounds, etc.)
Expertise in Handling Specialized and Hazardous Reagents
- Gaseous reagents, including selective catalytic hydrogenation
- Flammable reducing agents: LAH, DIBAL, AlH₃, Vitride, L-Selectride, Super-hydride, BH₃, LiHMDS, n-BuLi, sec-BuLi, t-BuLi, MeLi, LDA, LTMP
- Liquid ammonia-based chemistry
- Toxic metal-organic reagents (Mg, Zn, Cd, Hg, Sn, Bi)
- Fluorination agents: CF₃CHN₂, SF₄/HF, SbF₃, DAST, Morph- DAST, Deoxo-Fluor, CF₃I, Halothane, Freon-113
Custom Synthesis Request Processing
All requests are carefully evaluated by our R&D team to comprehensively satisfy new project objectives, criteria, and product specifications formulated by the customer to describe a desired compound or screening library, namely:
- Chemical name, structure, or CAS number
- Quantity needed
- Purity and quality control requirements
- Exclusivity and confidentiality terms
- Any other specific requirements
A detailed business offer based on the above requirements will be sent within a few working days, including general and/or confidentiality terms to protect the customer’s intellectual property and business interests.
In-house data availability: It should be pointed out that the project turnaround time and budget can be optimized upon the customer’s providing Life Chemicals with any appropriate data available in the literature, as well as existing synthetic route, if any, covering experimental details, e.g., reaction time, temperature, solvents and concentrations, work-up procedures, purification methods, yields, and analytical data.
Our synthetic team will summarize all relevant publications and data as soon as a PO is received. This will enable them to find the best synthetic route to obtain targeted products with chemical characteristics and purity levels defined under the contract.